AbstractState-of-the-art Machine Reading Comprehension (MRC) models for Open-domain Question Answering (QA) are typically trained for span selection using distantly supervised positive examples and heuristically retrieved negative examples. This training scheme possibly explains empirical observations that these models achieve a high recall amongst their top few predictions, but a low overall accuracy, motivating the need for answer re-ranking. We develop a successful re-ranking approach (RECONSIDER) for span-extraction tasks that improves upon the performance of MRC models, even beyond large-scale pre-training. RECONSIDER is trained on positive and negative examples extracted from high confidence MRC model predictions, and uses in-passage span annotations to perform span-focused re-ranking over a smaller candidate set. As a result, RECONSIDER learns to eliminate close false positives, achieving a new extractive state of the art on four QA tasks, with 45.5% Exact Match accuracy on Natural Questions with real user questions, and 61.7% on TriviaQA. We will release all related data, models, and code.