NeuroTrialNER: An Annotated Corpus for Neurological Diseases and Therapies in Clinical Trial Registries

Simona Doneva, Tilia Ellendorff, Beate Sick, Jean-Philippe Goldman, Amelia Cannon, Gerold Schneider, Benjamin Ineichen


Abstract
Extracting and aggregating information from clinical trial registries could provide invaluable insights into the drug development landscape and advance the treatment of neurologic diseases. However, achieving this at scale is hampered by the volume of available data and the lack of an annotated corpus to assist in the development of automation tools. Thus, we introduce NeuroTrialNER, a new and fully open corpus for named entity recognition (NER). It comprises 1093 clinical trial summaries sourced from ClinicalTrials.gov, annotated for neurological diseases, therapeutic interventions, and control treatments. We describe our data collection process and the corpus in detail. We demonstrate its utility for NER using large language models and achieve a close-to-human performance. By bridging the gap in data resources, we hope to foster the development of text processing tools that help researchers navigate clinical trials data more easily.
Anthology ID:
2024.emnlp-main.1050
Volume:
Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing
Month:
November
Year:
2024
Address:
Miami, Florida, USA
Editors:
Yaser Al-Onaizan, Mohit Bansal, Yun-Nung Chen
Venue:
EMNLP
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
18868–18890
Language:
URL:
https://aclanthology.org/2024.emnlp-main.1050
DOI:
Bibkey:
Cite (ACL):
Simona Doneva, Tilia Ellendorff, Beate Sick, Jean-Philippe Goldman, Amelia Cannon, Gerold Schneider, and Benjamin Ineichen. 2024. NeuroTrialNER: An Annotated Corpus for Neurological Diseases and Therapies in Clinical Trial Registries. In Proceedings of the 2024 Conference on Empirical Methods in Natural Language Processing, pages 18868–18890, Miami, Florida, USA. Association for Computational Linguistics.
Cite (Informal):
NeuroTrialNER: An Annotated Corpus for Neurological Diseases and Therapies in Clinical Trial Registries (Doneva et al., EMNLP 2024)
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PDF:
https://aclanthology.org/2024.emnlp-main.1050.pdf