<?xml version="1.0" encoding="UTF-8"?>
<modsCollection xmlns="http://www.loc.gov/mods/v3">
<mods ID="liao-etal-2025-reflectool">
    <titleInfo>
        <title>ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents</title>
    </titleInfo>
    <name type="personal">
        <namePart type="given">Yusheng</namePart>
        <namePart type="family">Liao</namePart>
        <role>
            <roleTerm authority="marcrelator" type="text">author</roleTerm>
        </role>
    </name>
    <name type="personal">
        <namePart type="given">Shuyang</namePart>
        <namePart type="family">Jiang</namePart>
        <role>
            <roleTerm authority="marcrelator" type="text">author</roleTerm>
        </role>
    </name>
    <name type="personal">
        <namePart type="given">Yanfeng</namePart>
        <namePart type="family">Wang</namePart>
        <role>
            <roleTerm authority="marcrelator" type="text">author</roleTerm>
        </role>
    </name>
    <name type="personal">
        <namePart type="given">Yu</namePart>
        <namePart type="family">Wang</namePart>
        <role>
            <roleTerm authority="marcrelator" type="text">author</roleTerm>
        </role>
    </name>
    <originInfo>
        <dateIssued>2025-07</dateIssued>
    </originInfo>
    <typeOfResource>text</typeOfResource>
    <relatedItem type="host">
        <titleInfo>
            <title>Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)</title>
        </titleInfo>
        <name type="personal">
            <namePart type="given">Wanxiang</namePart>
            <namePart type="family">Che</namePart>
            <role>
                <roleTerm authority="marcrelator" type="text">editor</roleTerm>
            </role>
        </name>
        <name type="personal">
            <namePart type="given">Joyce</namePart>
            <namePart type="family">Nabende</namePart>
            <role>
                <roleTerm authority="marcrelator" type="text">editor</roleTerm>
            </role>
        </name>
        <name type="personal">
            <namePart type="given">Ekaterina</namePart>
            <namePart type="family">Shutova</namePart>
            <role>
                <roleTerm authority="marcrelator" type="text">editor</roleTerm>
            </role>
        </name>
        <name type="personal">
            <namePart type="given">Mohammad</namePart>
            <namePart type="given">Taher</namePart>
            <namePart type="family">Pilehvar</namePart>
            <role>
                <roleTerm authority="marcrelator" type="text">editor</roleTerm>
            </role>
        </name>
        <originInfo>
            <publisher>Association for Computational Linguistics</publisher>
            <place>
                <placeTerm type="text">Vienna, Austria</placeTerm>
            </place>
        </originInfo>
        <genre authority="marcgt">conference publication</genre>
        <identifier type="isbn">979-8-89176-251-0</identifier>
    </relatedItem>
    <abstract>Large Language Models (LLMs) have shown promising potential in the medical domain, assisting with tasks like clinical note generation and patient communication. However, current LLMs are limited to text-based communication, hindering their ability to interact with diverse forms of information in clinical environments. Despite clinical agents succeeding in diverse signal interaction, they are oriented to a single clinical scenario and hence fail for broader applications. To evaluate clinical agents holistically, we propose ClinicalAgent Bench (CAB), a comprehensive medical agent benchmark consisting of 18 tasks across five key realistic clinical dimensions. Building on this, we introduce ReflectTool, a novel framework that excels at utilizing domain-specific tools within two stages. The first optimization stage progressively enlarges a long-term memory by saving successful solving processes and tool-wise experience of agents in a tiny pre-defined training set. In the following inference stage, ReflectTool can search for supportive successful demonstrations from already built long-term memory to guide the tool selection strategy, and a verifier improves the tool usage according to the tool-wise experience with two verification methods–iterative refinement and candidate selection. Extensive experiments on CAB demonstrate that ReflectTool surpasses the pure LLMs with more than 10 points and the well-established agent-based methods with 3 points, highlighting its adaptability and effectiveness in solving complex clinical tasks. Our code and datasets are available at https://github.com/BlueZeros/ReflecTool.</abstract>
    <identifier type="citekey">liao-etal-2025-reflectool</identifier>
    <identifier type="doi">10.18653/v1/2025.acl-long.663</identifier>
    <location>
        <url>https://aclanthology.org/2025.acl-long.663/</url>
    </location>
    <part>
        <date>2025-07</date>
        <extent unit="page">
            <start>13507</start>
            <end>13531</end>
        </extent>
    </part>
</mods>
</modsCollection>

%0 Conference Proceedings
%T ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents
%A Liao, Yusheng
%A Jiang, Shuyang
%A Wang, Yanfeng
%A Wang, Yu
%Y Che, Wanxiang
%Y Nabende, Joyce
%Y Shutova, Ekaterina
%Y Pilehvar, Mohammad Taher
%S Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
%D 2025
%8 July
%I Association for Computational Linguistics
%C Vienna, Austria
%@ 979-8-89176-251-0
%F liao-etal-2025-reflectool
%X Large Language Models (LLMs) have shown promising potential in the medical domain, assisting with tasks like clinical note generation and patient communication. However, current LLMs are limited to text-based communication, hindering their ability to interact with diverse forms of information in clinical environments. Despite clinical agents succeeding in diverse signal interaction, they are oriented to a single clinical scenario and hence fail for broader applications. To evaluate clinical agents holistically, we propose ClinicalAgent Bench (CAB), a comprehensive medical agent benchmark consisting of 18 tasks across five key realistic clinical dimensions. Building on this, we introduce ReflectTool, a novel framework that excels at utilizing domain-specific tools within two stages. The first optimization stage progressively enlarges a long-term memory by saving successful solving processes and tool-wise experience of agents in a tiny pre-defined training set. In the following inference stage, ReflectTool can search for supportive successful demonstrations from already built long-term memory to guide the tool selection strategy, and a verifier improves the tool usage according to the tool-wise experience with two verification methods–iterative refinement and candidate selection. Extensive experiments on CAB demonstrate that ReflectTool surpasses the pure LLMs with more than 10 points and the well-established agent-based methods with 3 points, highlighting its adaptability and effectiveness in solving complex clinical tasks. Our code and datasets are available at https://github.com/BlueZeros/ReflecTool.
%R 10.18653/v1/2025.acl-long.663
%U https://aclanthology.org/2025.acl-long.663/
%U https://doi.org/10.18653/v1/2025.acl-long.663
%P 13507-13531

Markdown (Informal)

[ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents](https://aclanthology.org/2025.acl-long.663/) (Liao et al., ACL 2025)

• ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents (Liao et al., ACL 2025)

ACL

• Yusheng Liao, Shuyang Jiang, Yanfeng Wang, and Yu Wang. 2025. ReflecTool: Towards Reflection-Aware Tool-Augmented Clinical Agents. In Proceedings of the 63rd Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 13507–13531, Vienna, Austria. Association for Computational Linguistics.