@inproceedings{yu-etal-2025-frame,
title = "{FRAME}: Feedback-Refined Agent Methodology for Enhancing Medical Research Insights",
author = "Yu, Chengzhang and
Zhang, Yiming and
Liu, Zhixin and
Ding, Zenghui and
Sun, Yining and
Jin, Zhanpeng",
editor = "Che, Wanxiang and
Nabende, Joyce and
Shutova, Ekaterina and
Pilehvar, Mohammad Taher",
booktitle = "Findings of the Association for Computational Linguistics: ACL 2025",
month = jul,
year = "2025",
address = "Vienna, Austria",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/2025.findings-acl.400/",
doi = "10.18653/v1/2025.findings-acl.400",
pages = "7690--7704",
ISBN = "979-8-89176-256-5",
abstract = "The automation of scientific research through large language models (LLMs) presents significant opportunities but faces critical challenges in knowledge synthesis and quality assurance. We introduce Feedback-Refined Agent Methodology (FRAME), a novel framework that enhances medical paper generation through iterative refinement and structured feedback. Our approach comprises three key innovations: (1) A structured dataset construction method that decomposes 4,287 medical papers into essential research components through iterative refinement; (2) A tripartite architecture integrating Generator, Evaluator, and Reflector agents that progressively improve content quality through metric-driven feedback; and (3) A comprehensive evaluation framework that combines statistical metrics with human-grounded benchmarks. Experimental results demonstrate FRAME{'}s effectiveness, achieving significant improvements over conventional approaches across multiple models (9.91{\%} average gain with DeepSeek V3, comparable improvements with GPT-4o Mini) and evaluation dimensions. Human evaluation confirms that FRAME-generated papers achieve quality comparable to human-authored works, with particular strength in synthesizing future research directions. The results demonstrated our work could efficiently assist medical research by building a robust foundation for automated medical research paper generation while maintaining rigorous academic standards."
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<abstract>The automation of scientific research through large language models (LLMs) presents significant opportunities but faces critical challenges in knowledge synthesis and quality assurance. We introduce Feedback-Refined Agent Methodology (FRAME), a novel framework that enhances medical paper generation through iterative refinement and structured feedback. Our approach comprises three key innovations: (1) A structured dataset construction method that decomposes 4,287 medical papers into essential research components through iterative refinement; (2) A tripartite architecture integrating Generator, Evaluator, and Reflector agents that progressively improve content quality through metric-driven feedback; and (3) A comprehensive evaluation framework that combines statistical metrics with human-grounded benchmarks. Experimental results demonstrate FRAME’s effectiveness, achieving significant improvements over conventional approaches across multiple models (9.91% average gain with DeepSeek V3, comparable improvements with GPT-4o Mini) and evaluation dimensions. Human evaluation confirms that FRAME-generated papers achieve quality comparable to human-authored works, with particular strength in synthesizing future research directions. The results demonstrated our work could efficiently assist medical research by building a robust foundation for automated medical research paper generation while maintaining rigorous academic standards.</abstract>
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%0 Conference Proceedings
%T FRAME: Feedback-Refined Agent Methodology for Enhancing Medical Research Insights
%A Yu, Chengzhang
%A Zhang, Yiming
%A Liu, Zhixin
%A Ding, Zenghui
%A Sun, Yining
%A Jin, Zhanpeng
%Y Che, Wanxiang
%Y Nabende, Joyce
%Y Shutova, Ekaterina
%Y Pilehvar, Mohammad Taher
%S Findings of the Association for Computational Linguistics: ACL 2025
%D 2025
%8 July
%I Association for Computational Linguistics
%C Vienna, Austria
%@ 979-8-89176-256-5
%F yu-etal-2025-frame
%X The automation of scientific research through large language models (LLMs) presents significant opportunities but faces critical challenges in knowledge synthesis and quality assurance. We introduce Feedback-Refined Agent Methodology (FRAME), a novel framework that enhances medical paper generation through iterative refinement and structured feedback. Our approach comprises three key innovations: (1) A structured dataset construction method that decomposes 4,287 medical papers into essential research components through iterative refinement; (2) A tripartite architecture integrating Generator, Evaluator, and Reflector agents that progressively improve content quality through metric-driven feedback; and (3) A comprehensive evaluation framework that combines statistical metrics with human-grounded benchmarks. Experimental results demonstrate FRAME’s effectiveness, achieving significant improvements over conventional approaches across multiple models (9.91% average gain with DeepSeek V3, comparable improvements with GPT-4o Mini) and evaluation dimensions. Human evaluation confirms that FRAME-generated papers achieve quality comparable to human-authored works, with particular strength in synthesizing future research directions. The results demonstrated our work could efficiently assist medical research by building a robust foundation for automated medical research paper generation while maintaining rigorous academic standards.
%R 10.18653/v1/2025.findings-acl.400
%U https://aclanthology.org/2025.findings-acl.400/
%U https://doi.org/10.18653/v1/2025.findings-acl.400
%P 7690-7704
Markdown (Informal)
[FRAME: Feedback-Refined Agent Methodology for Enhancing Medical Research Insights](https://aclanthology.org/2025.findings-acl.400/) (Yu et al., Findings 2025)
ACL