@inproceedings{huang-etal-2026-towards-explainable,
title = "Towards Explainable Diagnosis: A Self-learned Explanatory Knowledge Base Approach",
author = "Huang, Dongqi and
Zhou, Tong and
Jin, Zhuoran and
Shi, Shenghui and
Maoyujiao and
Liu, Kang and
Zhao, Jun and
Chen, Yubo",
editor = "Liakata, Maria and
Moreira, Viviane P. and
Zhang, Jiajun and
Jurgens, David",
booktitle = "Proceedings of the 64th Annual Meeting of the {A}ssociation for {C}omputational {L}inguistics (Volume 1: Long Papers)",
month = jul,
year = "2026",
address = "San Diego, California, United States",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/2026.acl-long.1700/",
pages = "36679--36700",
ISBN = "979-8-89176-390-6",
abstract = "Explainable diagnosis requires that authoritative medical knowledge provide the rationales linking a patient{'}s clinical manifestations to the diagnostic conclusion. Although large language models (LLMs) hold great potential to facilitate explainable diagnosis, their effectiveness is often constrained by insufficient diagnostic expertise. To address this limitation, we propose Self-learned Explainable Knowledge Augmented Diagnosis (SEKAD), a unified LLM-based framework for faithful and explainable diagnosis. Our approach builds a high-quality diagnostic knowledge base through a record-driven explanation learning paradigm, as well as applies this knowledge via an explanation-based diagnostic process that ensures faithful inference. Experiments on the DiReCT and JAMA benchmarks show that SEKAD consistently outperforms strong baselines across the metrics. In particular, on the DiReCT benchmark, SEKAD improves the explanation completeness metric from 64.5{\%} to 76.9{\%} over the best existing methods, highlighting its effectiveness in enhancing diagnostic explainability and showing that our text mining approach produces knowledge that is both reliable in quality and large in quantity."
}<?xml version="1.0" encoding="UTF-8"?>
<modsCollection xmlns="http://www.loc.gov/mods/v3">
<mods ID="huang-etal-2026-towards-explainable">
<titleInfo>
<title>Towards Explainable Diagnosis: A Self-learned Explanatory Knowledge Base Approach</title>
</titleInfo>
<name type="personal">
<namePart type="given">Dongqi</namePart>
<namePart type="family">Huang</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Tong</namePart>
<namePart type="family">Zhou</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Zhuoran</namePart>
<namePart type="family">Jin</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Shenghui</namePart>
<namePart type="family">Shi</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name>
<namePart>Maoyujiao</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Kang</namePart>
<namePart type="family">Liu</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Jun</namePart>
<namePart type="family">Zhao</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Yubo</namePart>
<namePart type="family">Chen</namePart>
<role>
<roleTerm authority="marcrelator" type="text">author</roleTerm>
</role>
</name>
<originInfo>
<dateIssued>2026-07</dateIssued>
</originInfo>
<typeOfResource>text</typeOfResource>
<relatedItem type="host">
<titleInfo>
<title>Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)</title>
</titleInfo>
<name type="personal">
<namePart type="given">Maria</namePart>
<namePart type="family">Liakata</namePart>
<role>
<roleTerm authority="marcrelator" type="text">editor</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Viviane</namePart>
<namePart type="given">P</namePart>
<namePart type="family">Moreira</namePart>
<role>
<roleTerm authority="marcrelator" type="text">editor</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">Jiajun</namePart>
<namePart type="family">Zhang</namePart>
<role>
<roleTerm authority="marcrelator" type="text">editor</roleTerm>
</role>
</name>
<name type="personal">
<namePart type="given">David</namePart>
<namePart type="family">Jurgens</namePart>
<role>
<roleTerm authority="marcrelator" type="text">editor</roleTerm>
</role>
</name>
<originInfo>
<publisher>Association for Computational Linguistics</publisher>
<place>
<placeTerm type="text">San Diego, California, United States</placeTerm>
</place>
</originInfo>
<genre authority="marcgt">conference publication</genre>
<identifier type="isbn">979-8-89176-390-6</identifier>
</relatedItem>
<abstract>Explainable diagnosis requires that authoritative medical knowledge provide the rationales linking a patient’s clinical manifestations to the diagnostic conclusion. Although large language models (LLMs) hold great potential to facilitate explainable diagnosis, their effectiveness is often constrained by insufficient diagnostic expertise. To address this limitation, we propose Self-learned Explainable Knowledge Augmented Diagnosis (SEKAD), a unified LLM-based framework for faithful and explainable diagnosis. Our approach builds a high-quality diagnostic knowledge base through a record-driven explanation learning paradigm, as well as applies this knowledge via an explanation-based diagnostic process that ensures faithful inference. Experiments on the DiReCT and JAMA benchmarks show that SEKAD consistently outperforms strong baselines across the metrics. In particular, on the DiReCT benchmark, SEKAD improves the explanation completeness metric from 64.5% to 76.9% over the best existing methods, highlighting its effectiveness in enhancing diagnostic explainability and showing that our text mining approach produces knowledge that is both reliable in quality and large in quantity.</abstract>
<identifier type="citekey">huang-etal-2026-towards-explainable</identifier>
<location>
<url>https://aclanthology.org/2026.acl-long.1700/</url>
</location>
<part>
<date>2026-07</date>
<extent unit="page">
<start>36679</start>
<end>36700</end>
</extent>
</part>
</mods>
</modsCollection>
%0 Conference Proceedings
%T Towards Explainable Diagnosis: A Self-learned Explanatory Knowledge Base Approach
%A Huang, Dongqi
%A Zhou, Tong
%A Jin, Zhuoran
%A Shi, Shenghui
%A Liu, Kang
%A Zhao, Jun
%A Chen, Yubo
%Y Liakata, Maria
%Y Moreira, Viviane P.
%Y Zhang, Jiajun
%Y Jurgens, David
%A Maoyujiao
%S Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers)
%D 2026
%8 July
%I Association for Computational Linguistics
%C San Diego, California, United States
%@ 979-8-89176-390-6
%F huang-etal-2026-towards-explainable
%X Explainable diagnosis requires that authoritative medical knowledge provide the rationales linking a patient’s clinical manifestations to the diagnostic conclusion. Although large language models (LLMs) hold great potential to facilitate explainable diagnosis, their effectiveness is often constrained by insufficient diagnostic expertise. To address this limitation, we propose Self-learned Explainable Knowledge Augmented Diagnosis (SEKAD), a unified LLM-based framework for faithful and explainable diagnosis. Our approach builds a high-quality diagnostic knowledge base through a record-driven explanation learning paradigm, as well as applies this knowledge via an explanation-based diagnostic process that ensures faithful inference. Experiments on the DiReCT and JAMA benchmarks show that SEKAD consistently outperforms strong baselines across the metrics. In particular, on the DiReCT benchmark, SEKAD improves the explanation completeness metric from 64.5% to 76.9% over the best existing methods, highlighting its effectiveness in enhancing diagnostic explainability and showing that our text mining approach produces knowledge that is both reliable in quality and large in quantity.
%U https://aclanthology.org/2026.acl-long.1700/
%P 36679-36700
Markdown (Informal)
[Towards Explainable Diagnosis: A Self-learned Explanatory Knowledge Base Approach](https://aclanthology.org/2026.acl-long.1700/) (Huang et al., ACL 2026)
ACL
- Dongqi Huang, Tong Zhou, Zhuoran Jin, Shenghui Shi, Maoyujiao, Kang Liu, Jun Zhao, and Yubo Chen. 2026. Towards Explainable Diagnosis: A Self-learned Explanatory Knowledge Base Approach. In Proceedings of the 64th Annual Meeting of the Association for Computational Linguistics (Volume 1: Long Papers), pages 36679–36700, San Diego, California, United States. Association for Computational Linguistics.