@inproceedings{lai-etal-2026-trace,
title = "{TRACE}: Deployable Tree-Relational Structure Enhancement for Oncology {LLM}s",
author = "Lai, Jizheng and
Li, Yingyun and
Qin, Ying and
Qian, Haiyang",
editor = "Atanasova, Pepa and
Haffari, Gholamreza and
Wang, Minghan",
booktitle = "Proceedings of the 2026 Conference on Empirical Methods in Natural Language Processing: Industry Track",
month = oct,
year = "2026",
address = "Budapest, Hungary",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/2026.emnlp-industry.230/",
pages = "3836--3853",
ISBN = "979-8-89176-460-6",
abstract = "Large language models are increasingly used in oncology applications, but their predictions are often weakly grounded in explicit medical structure. We present TRACE, a deployable tree-relational enhancement framework for oncology LLMs. TRACE separates expensive offline structure learning from lightweight online inference: oncology concepts and relations are organized into an updatable tree-relational structure, refined using LM-loss-derived evidence, and retrieved at inference time as compact prompt evidence. This design supports task-adaptive evidence selection without requiring supervised labels in the zero-shot setting. Across ten oncology classification tasks and one MedQuAD CancerGov QA benchmark, TRACE improves both label-free evaluation and supervised fine-tuning. Additional analyses show that TRACE improves over vanilla RAG and generic GraphRAG, remains useful under leakage-controlled METABRIC inputs, and produces interpretable evidence paths aligned with clinical reasoning. These results suggest that explicit, updatable medical structure is a practical path toward more accurate and auditable oncology LLM deployment."
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<abstract>Large language models are increasingly used in oncology applications, but their predictions are often weakly grounded in explicit medical structure. We present TRACE, a deployable tree-relational enhancement framework for oncology LLMs. TRACE separates expensive offline structure learning from lightweight online inference: oncology concepts and relations are organized into an updatable tree-relational structure, refined using LM-loss-derived evidence, and retrieved at inference time as compact prompt evidence. This design supports task-adaptive evidence selection without requiring supervised labels in the zero-shot setting. Across ten oncology classification tasks and one MedQuAD CancerGov QA benchmark, TRACE improves both label-free evaluation and supervised fine-tuning. Additional analyses show that TRACE improves over vanilla RAG and generic GraphRAG, remains useful under leakage-controlled METABRIC inputs, and produces interpretable evidence paths aligned with clinical reasoning. These results suggest that explicit, updatable medical structure is a practical path toward more accurate and auditable oncology LLM deployment.</abstract>
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%0 Conference Proceedings
%T TRACE: Deployable Tree-Relational Structure Enhancement for Oncology LLMs
%A Lai, Jizheng
%A Li, Yingyun
%A Qin, Ying
%A Qian, Haiyang
%Y Atanasova, Pepa
%Y Haffari, Gholamreza
%Y Wang, Minghan
%S Proceedings of the 2026 Conference on Empirical Methods in Natural Language Processing: Industry Track
%D 2026
%8 October
%I Association for Computational Linguistics
%C Budapest, Hungary
%@ 979-8-89176-460-6
%F lai-etal-2026-trace
%X Large language models are increasingly used in oncology applications, but their predictions are often weakly grounded in explicit medical structure. We present TRACE, a deployable tree-relational enhancement framework for oncology LLMs. TRACE separates expensive offline structure learning from lightweight online inference: oncology concepts and relations are organized into an updatable tree-relational structure, refined using LM-loss-derived evidence, and retrieved at inference time as compact prompt evidence. This design supports task-adaptive evidence selection without requiring supervised labels in the zero-shot setting. Across ten oncology classification tasks and one MedQuAD CancerGov QA benchmark, TRACE improves both label-free evaluation and supervised fine-tuning. Additional analyses show that TRACE improves over vanilla RAG and generic GraphRAG, remains useful under leakage-controlled METABRIC inputs, and produces interpretable evidence paths aligned with clinical reasoning. These results suggest that explicit, updatable medical structure is a practical path toward more accurate and auditable oncology LLM deployment.
%U https://aclanthology.org/2026.emnlp-industry.230/
%P 3836-3853
Markdown (Informal)
[TRACE: Deployable Tree-Relational Structure Enhancement for Oncology LLMs](https://aclanthology.org/2026.emnlp-industry.230/) (Lai et al., EMNLP 2026)
ACL