Right Diagnoses, Decorative Reasoning: A Perturbation Audit of Medical Chain-of-Thought

Mengzhu Xu, Jifan Gao, Xia Jiang, Yaoxin Wu, Xi Long


Abstract
Clinicians read chain-of-thought (CoT) rationales as evidence of medical reasoning, but whether the visible chain plays that role is rarely tested. General-domain CoT-faithfulness probes ignore clinical cost, and medical LLM evaluations treat the chain as a black box. We close this gap with a medical perturbation audit: a 30-operator battery edits both the chain and the question with clinically motivated operators (severity reversal, negation flip, demographic swap, evidence ablation), paired with a chain-update × answer-flip joint analysis that classifies each model by its failure mode. Applied to 14 LLMs on four medical QA benchmarks, three independent tests converge: the Chain-Decoupling Rate (CDR; chain does not register the edit and the answer does not flip) is 72.9% panel-wide on M2/M4/M5 destructive edits, chain corruption leaves accuracy unchanged, and removing CoT prompting does not reduce accuracy. Two board-certified clinicians re-annotate N=197 perturbed questions; 98.5% leave the gold defensible. The pattern holds across medical and reasoning fine-tuning, scale, and the closed-source subset. Our framework and CDR provide a reusable yardstick for auditing whether medical CoT is faithful or merely documentation.
Anthology ID:
2026.emnlp-main.334
Volume:
Proceedings of the 2026 Conference on Empirical Methods in Natural Language Processing
Month:
October
Year:
2026
Address:
Budapest, Hungary
Editors:
Hung-Yi Lee, Sunipa Dev, Jessy Li, Desmond Elliott
Venue:
EMNLP
SIG:
SIGDAT
Publisher:
Association for Computational Linguistics
Note:
Pages:
7689–7707
Language:
URL:
https://aclanthology.org/2026.emnlp-main.334/
DOI:
Bibkey:
Cite (ACL):
Mengzhu Xu, Jifan Gao, Xia Jiang, Yaoxin Wu, and Xi Long. 2026. Right Diagnoses, Decorative Reasoning: A Perturbation Audit of Medical Chain-of-Thought. In Proceedings of the 2026 Conference on Empirical Methods in Natural Language Processing, pages 7689–7707, Budapest, Hungary. Association for Computational Linguistics.
Cite (Informal):
Right Diagnoses, Decorative Reasoning: A Perturbation Audit of Medical Chain-of-Thought (Xu et al., EMNLP 2026)
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PDF:
https://aclanthology.org/2026.emnlp-main.334.pdf