Puzzles to Paradigms: A Survey of Human–Agent Collaboration in Scientific Innovation

Zhenni Liang, Haoxuan Zhang, Haihua Chen, Ting Xiao, Junhua Ding, Yang Zhang


Abstract
Agentic AI systems are increasingly embedded in scientific workflows, including literature synthesis, hypothesis generation, tool use, writing, and peer review. However, existing surveys and evaluations often emphasize task performance while underexamining how humans and agents coordinate under different epistemic conditions of scientific work. This survey introduces **CSCW**×**Kuhn**, a coordination-aware framework that connects computer-supported cooperative work dimensions with distinct scientific contexts. Using this framework, we synthesize recent human–agent systems and benchmarks to examine how coordination demands and failure risks may vary across contexts. Our synthesis identifies five recurring failure modes: procedural drift, grounding substitution, evaluative flattening, proxy optimization, and epistemic black-boxing, and argues for evaluations that move beyond task accuracy and toward grounding, provenance, disagreement preservation, and long-horizon scientific reliability. Our corpus and coding artifact are available at https://github.com/jenlia024/CSCWxKuhn-artifact.
Anthology ID:
2026.findings-emnlp.1645
Volume:
Findings of the Association for Computational Linguistics: EMNLP 2026
Month:
October
Year:
2026
Address:
Budapest, Hungary
Editors:
Hung-Yi Lee, Sunipa Dev, Jessy Li, Desmond Elliott
Venue:
Findings
SIG:
SIGDAT
Publisher:
Association for Computational Linguistics
Note:
Pages:
35017–35041
Language:
URL:
https://aclanthology.org/2026.findings-emnlp.1645/
DOI:
Bibkey:
Cite (ACL):
Zhenni Liang, Haoxuan Zhang, Haihua Chen, Ting Xiao, Junhua Ding, and Yang Zhang. 2026. Puzzles to Paradigms: A Survey of Human–Agent Collaboration in Scientific Innovation. In Findings of the Association for Computational Linguistics: EMNLP 2026, pages 35017–35041, Budapest, Hungary. Association for Computational Linguistics.
Cite (Informal):
Puzzles to Paradigms: A Survey of Human–Agent Collaboration in Scientific Innovation (Liang et al., Findings 2026)
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PDF:
https://aclanthology.org/2026.findings-emnlp.1645.pdf