Reverse Probing: Supervised Token-level Uncertainty Quantification for Large Language Models in Clinical Text

Bushi Xiao, Sarvesh Soni, Daisy Zhe Wang


Abstract
As large language models are increasingly deployed for clinical text, ensuring they can reliably signal their own uncertainty becomes critical. Most existing uncertainty quantification (UQ) methods are designed for open-domain generation and cannot localize uncertainty at the token or span level in long clinical text. We propose Reverse Probing, the first uncertainty quantification framework specialized for clinical summarization, which estimates token-level uncertainty directly from pre-existing clinical summaries. Rather than sampling new outputs, Reverse Probing treats the text as a probe into the model’s internal state, extracting uncertainty features from four categories of signals. We evaluate Reverse Probing on two expert-annotated clinical datasets and outperform eight adapted baselines, achieving up to 4× higher AUPRC while running over 15× faster than sampling-based methods. Feature analysis reveals that the log-logit difference induced by the source record and the neighborhood context are the most consistent predictors across all models. This study offers interpretable insights into how models internally respond to unsupported clinical content.
Anthology ID:
2026.findings-emnlp.407
Volume:
Findings of the Association for Computational Linguistics: EMNLP 2026
Month:
October
Year:
2026
Address:
Budapest, Hungary
Editors:
Hung-Yi Lee, Sunipa Dev, Jessy Li, Desmond Elliott
Venue:
Findings
SIG:
SIGDAT
Publisher:
Association for Computational Linguistics
Note:
Pages:
8599–8616
Language:
URL:
https://aclanthology.org/2026.findings-emnlp.407/
DOI:
Bibkey:
Cite (ACL):
Bushi Xiao, Sarvesh Soni, and Daisy Zhe Wang. 2026. Reverse Probing: Supervised Token-level Uncertainty Quantification for Large Language Models in Clinical Text. In Findings of the Association for Computational Linguistics: EMNLP 2026, pages 8599–8616, Budapest, Hungary. Association for Computational Linguistics.
Cite (Informal):
Reverse Probing: Supervised Token-level Uncertainty Quantification for Large Language Models in Clinical Text (Xiao et al., Findings 2026)
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PDF:
https://aclanthology.org/2026.findings-emnlp.407.pdf