@inproceedings{liu-etal-2026-ns,
title = "{NS}-Copilot: An {LLM}-Driven Agent System for Autonomous Neuroscience Analysis",
author = "Liu, Wuche and
Qiao, Yiran and
Hou, Linlin and
Yang, Rui and
Pu, Shusen and
Wang, Song and
Ma, Jing",
editor = "Lee, Hung-Yi and
Dev, Sunipa and
Li, Jessy and
Elliott, Desmond",
booktitle = "Findings of the {A}ssociation for {C}omputational {L}inguistics: {EMNLP} 2026",
month = oct,
year = "2026",
address = "Budapest, Hungary",
publisher = "Association for Computational Linguistics",
url = "https://aclanthology.org/2026.findings-emnlp.751/",
pages = "15809--15828",
ISBN = "979-8-89176-462-0",
abstract = "AI is rapidly advancing neuroscience, yet many laboratories fail to fully unleash its potential due to significant interdisciplinary barriers. While pre-trained neural models for physiological data are progressing quickly, their heterogeneous architectures and modality-specific constraints hinder systematic integration, selection, and evaluation. Despite recent advances in large language model (LLM)-based agent systems for intelligent scientific applications, existing approaches often still lack the domain expertise required to effectively select and coordinate diverse neuroscience pre-trained models and handle unique data types in this domain. We present NS-Copilot, an LLM-driven multi-agent system for neuroscience analysis that autonomously supports end-to-end workflows for diverse professional tasks. It unifies domain-specific pre-trained models and supports key neuroscience modalities, including EEG and extracellular spike data, through a natural-language interface. Given raw data and a task description, NS-Copilot orchestrates agents with specialized roles for planning, adaptive control, code generation, and result synthesis, enabling analysis without dataset-specific heuristics. We evaluate NS-Copilot on neuroscience benchmarks spanning Alzheimer{'}s disease, Parkinson{'}s disease, and working memory spike decoding. Across 8 trials per task, the system consistently outperforms strong baselines on the primary metric, demonstrating the ability of NS-Copilot for effective and scalable neuroscience analysis."
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<abstract>AI is rapidly advancing neuroscience, yet many laboratories fail to fully unleash its potential due to significant interdisciplinary barriers. While pre-trained neural models for physiological data are progressing quickly, their heterogeneous architectures and modality-specific constraints hinder systematic integration, selection, and evaluation. Despite recent advances in large language model (LLM)-based agent systems for intelligent scientific applications, existing approaches often still lack the domain expertise required to effectively select and coordinate diverse neuroscience pre-trained models and handle unique data types in this domain. We present NS-Copilot, an LLM-driven multi-agent system for neuroscience analysis that autonomously supports end-to-end workflows for diverse professional tasks. It unifies domain-specific pre-trained models and supports key neuroscience modalities, including EEG and extracellular spike data, through a natural-language interface. Given raw data and a task description, NS-Copilot orchestrates agents with specialized roles for planning, adaptive control, code generation, and result synthesis, enabling analysis without dataset-specific heuristics. We evaluate NS-Copilot on neuroscience benchmarks spanning Alzheimer’s disease, Parkinson’s disease, and working memory spike decoding. Across 8 trials per task, the system consistently outperforms strong baselines on the primary metric, demonstrating the ability of NS-Copilot for effective and scalable neuroscience analysis.</abstract>
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%0 Conference Proceedings
%T NS-Copilot: An LLM-Driven Agent System for Autonomous Neuroscience Analysis
%A Liu, Wuche
%A Qiao, Yiran
%A Hou, Linlin
%A Yang, Rui
%A Pu, Shusen
%A Wang, Song
%A Ma, Jing
%Y Lee, Hung-Yi
%Y Dev, Sunipa
%Y Li, Jessy
%Y Elliott, Desmond
%S Findings of the Association for Computational Linguistics: EMNLP 2026
%D 2026
%8 October
%I Association for Computational Linguistics
%C Budapest, Hungary
%@ 979-8-89176-462-0
%F liu-etal-2026-ns
%X AI is rapidly advancing neuroscience, yet many laboratories fail to fully unleash its potential due to significant interdisciplinary barriers. While pre-trained neural models for physiological data are progressing quickly, their heterogeneous architectures and modality-specific constraints hinder systematic integration, selection, and evaluation. Despite recent advances in large language model (LLM)-based agent systems for intelligent scientific applications, existing approaches often still lack the domain expertise required to effectively select and coordinate diverse neuroscience pre-trained models and handle unique data types in this domain. We present NS-Copilot, an LLM-driven multi-agent system for neuroscience analysis that autonomously supports end-to-end workflows for diverse professional tasks. It unifies domain-specific pre-trained models and supports key neuroscience modalities, including EEG and extracellular spike data, through a natural-language interface. Given raw data and a task description, NS-Copilot orchestrates agents with specialized roles for planning, adaptive control, code generation, and result synthesis, enabling analysis without dataset-specific heuristics. We evaluate NS-Copilot on neuroscience benchmarks spanning Alzheimer’s disease, Parkinson’s disease, and working memory spike decoding. Across 8 trials per task, the system consistently outperforms strong baselines on the primary metric, demonstrating the ability of NS-Copilot for effective and scalable neuroscience analysis.
%U https://aclanthology.org/2026.findings-emnlp.751/
%P 15809-15828
Markdown (Informal)
[NS-Copilot: An LLM-Driven Agent System for Autonomous Neuroscience Analysis](https://aclanthology.org/2026.findings-emnlp.751/) (Liu et al., Findings 2026)
ACL