Isolation as a First-Class Principle for LLM-Agent System Safety: Concepts, Taxonomy, Challenges and Future Directions

Huihao Jing, Wenbin Hu, Shaojin Chen, Haochen Shi, Sirui Zhang, Hanyu Yang, Changxuan Fan, Zhongwei Xie, Hongyu Luo, Wun Yu Chan, Wei Fan, Haoran Li, Yangqiu Song


Abstract
The capability of LLM agents to function as the ”brain“ of a system fundamentally expands the scope of analysis beyond a standalone model. Consequently, safety is no longer only about input–output content alignment. It also concerns system behavior and real-world execution outcomes. However, the current literature is fragmented across attack types, applications, and benchmarks. This makes it hard to explain why failures such as prompt injection, tool misuse, and memory poisoning often share the same structural cause, and how they spread through an agent workflow. In this survey, we treat isolation as a first-class principle for LLM-agent system safety. By isolation, we refer to the separation of user inputs, tool access, execution channels, inter-agent communication, and environment-originated context. We organize the literature with a boundary-centric taxonomy of five boundaries: user-agent, agent-tool, agent-execution, agent-agent, and system-environment. This view helps identify where the loss of isolation first occurs, how compromise propagates across boundaries, and which defenses are most relevant at each interface. We also summarize cross-boundary failure paths, discuss open challenges, and outline a research agenda for isolation-by-construction in future agent systems.
Anthology ID:
2026.findings-emnlp.976
Volume:
Findings of the Association for Computational Linguistics: EMNLP 2026
Month:
October
Year:
2026
Address:
Budapest, Hungary
Editors:
Hung-Yi Lee, Sunipa Dev, Jessy Li, Desmond Elliott
Venue:
Findings
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SIGDAT
Publisher:
Association for Computational Linguistics
Note:
Pages:
20631–20650
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URL:
https://aclanthology.org/2026.findings-emnlp.976/
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Cite (ACL):
Huihao Jing, Wenbin Hu, Shaojin Chen, Haochen Shi, Sirui Zhang, Hanyu Yang, Changxuan Fan, Zhongwei Xie, Hongyu Luo, Wun Yu Chan, Wei Fan, Haoran Li, and Yangqiu Song. 2026. Isolation as a First-Class Principle for LLM-Agent System Safety: Concepts, Taxonomy, Challenges and Future Directions. In Findings of the Association for Computational Linguistics: EMNLP 2026, pages 20631–20650, Budapest, Hungary. Association for Computational Linguistics.
Cite (Informal):
Isolation as a First-Class Principle for LLM-Agent System Safety: Concepts, Taxonomy, Challenges and Future Directions (Jing et al., Findings 2026)
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https://aclanthology.org/2026.findings-emnlp.976.pdf