Beyond Binary ADHD Classification: Multimodal Phenotyping in a Clinical Psychiatric Cohort

Siyu Li, E. Margaret Perkoff, Lyle Ungar


Abstract
High-quality automated ADHD assessment has the potential to increase screening rates among individuals in clinical settings, but these methods are far from perfect. Binary classification methods can obscure differences among clinical populations, and computational ADHD studies often evaluate binary diagnostic prediction against neurotypical controls. Such comparisons can obscure which measurements remain useful when ADHD is distinguished from other psychiatric conditions. We address these gaps using the HYPERAKTIV clinical cohort and four measurements: the Conners Continuous Performance Test II (CPT-II), self-report questionnaires, heart-rate variability (HRV), and actigraphy. We examine three aspects of multimodal ADHD assessments: what information different modalities provide for binary ADHD classification, how well multimodal measurements distinguish the clinical groups, and how patterns in the features relate to clinical diagnosis in unsupervised analysis. CPT-II combined with self-report achieved the highest binary AUC (0.908), but was not reliably better than self-report alone under nested cross-validation. In the three-way task, the inattentive group was the hardest to identify. Clustering produced feature profiles that crossed diagnostic groups. These results suggest that adding more modalities does not necessarily improve classification and that feature-space structure does not always align with diagnostic groups.
Anthology ID:
2026.multipsyche-1.6
Volume:
Proceedings of the 1st Workshop on Multimodal, Multilingual, and Multicultural Mental Health and Psychotherapy (MultiPsyche)
Month:
November
Year:
2026
Address:
Hengqin, Zhuhai, China
Editors:
Zimu Wang, Yiwen Jiang, Yaling Shen, Xiangyu Zhao, Stephanie Fong, Xin Sun, Yi Zhou, Shaoxiong Ji, Robert Desimone, Barnaby Nelson, Dominic Dwyer, Zongyuan Ge
Venues:
MultiPsyche | WS
SIG:
Publisher:
Association for Computational Linguistics
Note:
Pages:
55–68
Language:
URL:
https://aclanthology.org/2026.multipsyche-1.6/
DOI:
Bibkey:
Cite (ACL):
Siyu Li, E. Margaret Perkoff, and Lyle Ungar. 2026. Beyond Binary ADHD Classification: Multimodal Phenotyping in a Clinical Psychiatric Cohort. In Proceedings of the 1st Workshop on Multimodal, Multilingual, and Multicultural Mental Health and Psychotherapy (MultiPsyche), pages 55–68, Hengqin, Zhuhai, China. Association for Computational Linguistics.
Cite (Informal):
Beyond Binary ADHD Classification: Multimodal Phenotyping in a Clinical Psychiatric Cohort (Li et al., MultiPsyche 2026)
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PDF:
https://aclanthology.org/2026.multipsyche-1.6.pdf