Towards Conversational Patient History-Taking: Voice-Interactive AI Agents for Pre-visit Dementia Diagnostic Interviews

Andrew G. Breithaupt, Nayoung Choi, James D. Finch, Jeanne M. Powell, Arin L. Nelson, Oz A. Alon, Howard J. Rosen, Jinho D. Choi


Abstract
Patient history-taking is a critical yet time-intensive component of clinical diagnosis, frequently hindered by time-constrained clinical visits. We present an LLM-based voice-interactive conversational system for conducting semi-structured diagnostic interviews with older adults suspected of Alzheimer’s disease and related dementias (ADRD). The system features conditional conversation branching over specialist-developed interview scripts and interaction adaptations tailored for older adults. In a within-subjects study with 30 participants from a cognitive neurology clinic, we compare two LLM prompting strategies through dialogue analysis, assess user experience, and evaluate symptom elicitation against routine specialist interviews. Our findings reveal that prompting strategy distinctly shapes both conversational dynamics and symptom coverage. Together with high sensitivity scores and positive user experience ratings, these results demonstrate the feasibility and clinical potential of LLM-based conversational agents for scalable, patient-centered history-taking in ADRD care.
Anthology ID:
2026.sigdial-1.5
Volume:
Proceedings of the 27th Annual Meeting of the Special Interest Group on Discourse and Dialogue
Month:
August
Year:
2026
Address:
Atlanta, Georgia, USA
Editors:
Jinho D. Choi, Yun-Nung Chen, Kotaro Funakoshi, Ali Emami
Venue:
SIGDIAL
SIG:
SIGDIAL
Publisher:
Association for Computational Linguistics
Note:
Pages:
62–78
Language:
URL:
https://aclanthology.org/2026.sigdial-1.5/
DOI:
Bibkey:
Cite (ACL):
Andrew G. Breithaupt, Nayoung Choi, James D. Finch, Jeanne M. Powell, Arin L. Nelson, Oz A. Alon, Howard J. Rosen, and Jinho D. Choi. 2026. Towards Conversational Patient History-Taking: Voice-Interactive AI Agents for Pre-visit Dementia Diagnostic Interviews. In Proceedings of the 27th Annual Meeting of the Special Interest Group on Discourse and Dialogue, pages 62–78, Atlanta, Georgia, USA. Association for Computational Linguistics.
Cite (Informal):
Towards Conversational Patient History-Taking: Voice-Interactive AI Agents for Pre-visit Dementia Diagnostic Interviews (Breithaupt et al., SIGDIAL 2026)
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PDF:
https://aclanthology.org/2026.sigdial-1.5.pdf