Large language models (LLMs) pretrained on vast source code have achieved prominent progress in code intelligence. However, existing code LLMs have two main limitations. First, they often adopt a specific architecture (encoder-only or decoder-only) or rely on a unified encoder-decoder network for different downstream tasks, lacking the flexibility to operate in the optimal architecture for a specific task. Secondly, they often employ a limited set of pretraining objectives which might not be relevant to some tasks and hence result in substantial performance degrade. To address these limitations, we propose “CodeT5+”, a family of encoder-decoder LLMs for code in which component modules can be flexibly combined to suit a wide range of code tasks. Such flexibility is enabled by our proposed mixture of pretraining objectives, which cover span denoising, contrastive learning, text-code matching, and causal LM pretraining tasks, on both unimodal and bimodal multilingual code corpora. Furthermore, we propose to initialize CodeT5+ with frozen off-the-shelf LLMs without training from scratch to efficiently scale up our models, and explore instruction-tuning to align with natural language instructions. We extensively evaluate CodeT5+ on over 20 code-related benchmarks in different settings, including zero-shot, finetuning, and instruction-tuning. We observe state-of-the-art (SoTA) performance on various code-related tasks, and our instruction-tuned CodeT5+ 16B achieves new SoTA results of 35.0% pass@1 and 54.5% pass@10 on the HumanEval code generation task against other open code LLMs, even surpassing the OpenAI code-cushman-001 model.