Equipping Large Language Models (LLMs) with human-like personas is crucial for agentic applications, such as role-play and user simulation. Traditional prompt-based methods rely on descriptive conditioning by injecting static textual profiles, which often makes agents show generic behaviors due to a lack of realistic life memory. To fill this gap, we introduce memory-based conditioning, a paradigm inspired by the cognitive psychology, which replaces abstract profiles with an autobiographical memory base, enabling frozen LLMs to dynamically retrieve situation-relevant memory to guide their behaviors. We formalize its enabling task as customized lifelong memory synthesis and propose MemoryForge, a novel framework to synthesize such lifelong memory from brief target personas. MemoryForge has three key components: a context generator for socio-historical grounding, a life organizer for developmental coherence toward the target identity, and a multi-resolution simulator that balances broad temporal summaries with high-fidelity episodic experiences. Experiments on PersonaGym for role-play and SimulatorArena for user-simulation, show that the synthesized memory base by MemoryForge enables frozen LLMs to exhibit more human-like behaviors than strong descriptive conditioning baselines across multiple metrics and LLM backbones. Code is available here.

Post-training is essential for enabling large language models (LLMs) to follow human instructions. However, its effectiveness depends on high-quality instruction data, which is challenging to obtain in the real world due to privacy concerns, data scarcity, and high annotation costs. To fill this gap, inspired by the recent success of using LLMs to simulate human society, we propose MATRIX, a multi-agent simulator that automatically generates diverse text-based scenarios, capturing a wide range of real-world human needs in a realistic and scalable manner. Leveraging these outputs, we introduce a novel scenario-driven instruction generator MATRIX-Gen for controllable and highly realistic data synthesis. Extensive experiments demonstrate that our framework effectively generates both general and domain-specific data. On AlpacaEval 2 and Arena-Hard benchmarks, Llama-3-8B-Base, post-trained on datasets synthesized by MATRIX-Gen with just 20K instruction-response pairs, outperforms Meta’s Llama-3-8B-Instruct model, which was trained on over 10M pairs.