The utilization of large language models for medical dialogue generation has attracted considerable attention due to its potential to enhance response richness and coherence. While previous studies have made strides in optimizing model performance, there is a pressing need to bolster the model’s capacity for diagnostic logic to ensure patient safety. In response to this need, we propose an approach termed preference learning from process feedback (PLPF), which involves integrating the doctor’s diagnostic logic into LLMs. PLPF encompasses three key components: rule modeling, preference data generation, and preference alignment. These components collectively serve to train the model to adhere to the diagnostic process. Our experimental results, utilizing Standardized Patient Testing, demonstrate that PLPF enhances the diagnostic accuracy of the baseline model in medical conversations by 17.6%, surpassing the performance of traditional approaches. Moreover, PLPF exhibits effectiveness in both multi-round and single-round dialogue tasks, thereby highlighting its potential in improving medical dialogue generation. Our dataset is available at https://github.com/Chengfeng-Dou/SpTesting.

Large Language Models (LLMs) have made significant progress recently. However, their practical use in healthcare is hindered by their tendency to generate hallucinations. One specific type, called snowballing hallucination, occurs when LLMs encounter misleading information, and poses a security threat to LLMs. To understand how well LLMs can resist these hallucination, we create the Chinese Medical Hallucination Evaluation benchmark (CMHE). This benchmark can be used to evaluate LLMs’ ability to detect medical hallucinations, make accurate diagnoses in noisy conditions, and provide plausible explanations. The creation of this benchmark involves a combination of manual and model-based approaches. In addition, we use ICD-10 as well as MeSH, two specialized glossaries, to aid in the evaluation. Our experiments show that the LLM struggles to identify fake medical terms and makes poor diagnoses in distracting environments. However, improving the model’s understanding of medical concepts can help it resist interference to some extent.

Reasoning about events and their relations attracts surging research efforts since it is regarded as an indispensable ability to fulfill various event-centric or common-sense reasoning tasks. However, these tasks often suffer from limited data availability due to the labor-intensive nature of their annotations. Consequently, recent studies have explored knowledge transfer approaches within a multi-task learning framework to address this challenge. Although such methods have achieved acceptable results, such brute-force solutions struggle to effectively transfer event-relational knowledge due to the vast array of inter-event relations (e.g. temporal, causal, conditional) and reasoning formulations (e.g. discriminative, abductive, ending prediction). To enhance knowledge transfer and enable zero-shot generalization among various combinations, in this work we propose a novel unified framework, called UNIEVENT. Inspired by prefix-based multitask learning, our approach organizes event relational reasoning tasks into a coordinate system with multiple axes, representing inter-event relations and reasoning formulations. We then train a unified text-to-text generative model that utilizes coordinate-assigning prefixes for each task. By leveraging our adapted prefixes, our unified model achieves state-of-the-art or competitive performance on both zero-shot and supervised reasoning tasks, as demonstrated in extensive experiments

Extracting event causality underlies a broad spectrum of natural language processing applications. Cutting-edge methods break this task into Event Detection and Event Causality Identification. Although the pipelined solutions succeed in achieving acceptable results, the inherent nature of separating the task incurs limitations. On the one hand, it suffers from the lack of cross-task dependencies and may cause error propagation. On the other hand, it predicts events and relations separately, undermining the integrity of the event causality graph (ECG). To address such issues, in this paper, we propose an approach for Structure-Aware Event Causality Generation (SEAG). With a graph linearization module, we generate the ECG structure in a way of text2text generation based on a pre-trained language model. To foster the structural representation of the ECG, we introduce the novel Causality Structural Discrimination training paradigm in which we perform structural discriminative training alongside auto-regressive generation enabling the model to distinguish from constructed incorrect ECGs. We conduct experiments on three datasets. The experimental results demonstrate the effectiveness of structural event causality generation and the causality structural discrimination training.

The patient-centered medical dialogue systems strive to offer diagnostic interpretation services to users who are less knowledgeable about medical knowledge, through emphasizing the importance of providing responses specific to the patients. It is difficult for the large language models (LLMs) to guarantee the specificity of responses in spite of its promising performance even in some tasks in medical field. Inspired by in-context learning, we propose PlugMed, a Plug-and-Play Medical Dialogue System, for addressing this challenge. PlugMed is equipped with two modules, the prompt generation (PG) module and the response ranking (RR) module, to enhances LLMs’ dialogue strategies for improving the specificity of the dialogue. The PG module is designed to stimulate the imitative ability of LLMs by providing them with real dialogues from similar patients as prompts. The RR module incorporates fine-tuned small model as response filter to enable the selection of appropriate responses generated by LLMs. Furthermore, we introduce a new evaluation method based on matching both user’s intent and high-frequency medical term to effectively assess the specificity of the responses. We conduct experimental evaluations on three medical dialogue datasets, and the results, including both automatic and human evaluation, demonstrate the effectiveness of our approach.