The amount of biomedical literature has vastly increased over the past few decades. As a result, the sheer quantity of accessible information is overwhelming, and complicates manual information retrieval. Automated methods seek to speed up information retrieval from biomedical literature. However, such automated methods are still too time-intensive to survey all existing biomedical literature. We present a methodology for automatically generating literature queries that select relevant papers based on biological data. By using differentially expressed genes to inform our literature searches, we focus information extraction on mechanistic signaling details that are crucial for the disease or context of interest.