Deep learning models trained on extensive Electronic Health Records (EHR) data have achieved high accuracy in diagnosis prediction, offering the potential to assist clinicians in decision-making and treatment planning. However, these models lack two crucial features that clinicians highly value: interpretability and interactivity. The “black-box” nature of these models makes it difficult for clinicians to understand the reasoning behind predictions, limiting their ability to make informed decisions. Additionally, the absence of interactive mechanisms prevents clinicians from incorporating their own knowledge and experience into the decision-making process. To address these limitations, we propose II-KEA, a knowledge-enhanced agent-driven causal discovery framework that integrates personalized knowledge databases and agentic LLMs. II-KEA enhances interpretability through explicit reasoning and causal analysis, while also improving interactivity by allowing clinicians to inject their knowledge and experience through customized knowledge bases and prompts. II-KEA is evaluated on both MIMIC-III and MIMIC-IV, demonstrating superior performance along with enhanced interpretability and interactivity, as evidenced by its strong results from extensive case studies.

Despite recent success in applying large language models (LLMs) to electronic health records (EHR), most systems focus primarily on assessment rather than treatment planning. We identify three critical limitations in current approaches: they generate treatment plans in a single pass rather than following the sequential reasoning process used by clinicians; they rarely incorporate patient-specific historical context; and they fail to effectively distinguish between subjective and objective clinical information. Motivated by the SOAP methodology (Subjective, Objective, Assessment, Plan), we introduce MedPlan, a novel framework that structures LLM reasoning to align with real-life clinician workflows. Our approach employs a two-stage architecture that first generates a clinical assessment based on patient symptoms and objective data, then formulates a structured treatment plan informed by this assessment and enriched with patient-specific information through retrieval-augmented generation. Comprehensive evaluation demonstrates that our method significantly outperforms baseline approaches in both assessment accuracy and treatment plan quality. Our demo system and code are available at https://github.com/JustinHsu1019/MedPlan.

Relational triple extraction is critical to understanding massive text corpora and constructing large-scale knowledge graph, which has attracted increasing research interest. However, existing studies still face some challenging issues, including information loss, error propagation and ignoring the interaction between entity and relation. To intuitively explore the above issues and address them, in this paper, we provide a revealing insight into relational triple extraction from a stereoscopic perspective, which rationalizes the occurrence of these issues and exposes the shortcomings of existing methods. Further, a novel model is proposed for relational triple extraction, which maps relational triples to a three-dimension (3-D) space and leverages three decoders to extract them, aimed at simultaneously handling the above issues. A series of experiments are conducted on five public datasets, demonstrating that the proposed model outperforms the recent advanced baselines.