This paper presents a methodological approach for establishing control corpora in the context of depression detection in the Modern Greek language. We discuss various methods used to create control corpora, focusing on the challenge of selecting representative samples from the general population when the target reference is the depressed population. Our approach includes traditional random selection among Twitter users, as well as an innovative method for creating topic-oriented control corpora. Through this study, we provide insights into the development of control corpora, offering valuable considerations for researchers working on similar projects in linguistic analysis and mental health studies. In addition, we identify several dominant topics in the depressed population such as religion, sentiments, health and digestion, which seem to align with findings consistently reported in the literature