Word senses are typically defined with textual definitions for human consumption and, in computational lexicons, put in context via lexical-semantic relations such as synonymy, antonymy, hypernymy, etc. In this paper we embrace a radically different paradigm that provides a slot-filler structure, called “semagram”, to define the meaning of words in terms of their prototypical semantic information. We propose a semagram-based knowledge model composed of 26 semantic relationships which integrates features from a range of different sources, such as computational lexicons and property norms. We describe an annotation exercise regarding 50 concepts over 10 different categories and put forward different automated approaches for extending the semagram base to thousands of concepts. We finally evaluated the impact of the proposed resource on a semantic similarity task, showing significant improvements over state-of-the-art word embeddings.