Guanhua Chen

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2026

Clinical language models can achieve strong in-hospital accuracy yet fail under deployment shifts because they exploit note-specific artifacts (e.g., templates, separators, boilerplate) that do not reflect patient state. We propose CAST (Concept-guided Artifact Suppression Tuning), an SAE-based framework for auditable clinical text classification. CAST uses Sparse Autoencoders to expose sparse, human-auditable features from intermediate Transformer activations, labels SAE latents with an LLM-assisted interpretation pipeline and ICD-10 retrieval constraints, suppresses verified artifact latents via residual subtraction during fine-tuning, and provides post-hoc perconcept attributions for auditing model decisions. On MIMIC-IV discharge-note mortality prediction, CAST improves over its corresponding fine-tuned encoder baselines and remains competitive with strong LLM baselines, while producing a feature-level audit trail of the clinical concepts that support each prediction and the artifact concepts suppressed during training.

2025

Large language models (LLMs) often behave inconsistently across inputs, indicating uncertainty and motivating the need for its quantification in high-stakes settings. Prior work on calibration and uncertainty quantification often focuses on individual models, overlooking the potential of model diversity. We hypothesize that LLMs make complementary predictions due to differences in training and the Zipfian nature of language, and that aggregating their outputs leads to more reliable uncertainty estimates. To leverage this, we propose MUSE (Multi-LLM Uncertainty via Subset Ensembles), a simple information-theoretic method that uses Jensen-Shannon Divergence to identify and aggregate well-calibrated subsets of LLMs. Experiments on binary prediction tasks demonstrate improved calibration and predictive performance compared to single-model and naive ensemble baselines. In addition, we explore using MUSE as guided signals with chain-of-thought distillation to fine-tune LLMs for calibration. MUSE is available at: https://github.com/LARK-NLP-Lab/MUSE.