Small language models (SLMs) are increasingly adopted for machine translation due to their lower computational and deployment costs, yet a focused and systematic evaluation for English-to-Portuguese remains limited. We benchmarked dozens of SLMs (135M–20B parameters) across multiple architectures and quantization schemes (FP16, Q8_0, Q4_K_M) on two datasets: FLORES-101 (Portuguese subset, 1,012 sentences) and the multidomain OPUS-100 dataset (~10k sentences). We computed lexical and semantic metrics (BLEU, chrF, and BERTScore) and assessed statistical differences using non-parametric Friedman tests over paired sentence-level scores, followed by Wilcoxon signed-rank post-hoc comparisons with Holm correction. Normality assumptions are evaluated using the Shapiro–Wilk test. Our results strongly suggest that 8-bit quantization (Q8_0) preserves semantic quality with negligible average loss, while 4-bit quantization (Q4_K_M) reaches statistical significance in roughly half of model configurations, paired effect sizes (Cliff’s δ) remain negligible to small in magnitude, with measurable degradation concentrated in lower-capacity models. Model scale exhibits only a weak correlation with translation quality: medium-sized models can match or outperform larger ones depending on model family and pretraining. These findings highlight trade-offs between efficiency and quality and inform the design of practical English–to-Portuguese translation pipelines based on SLMs.