Recommending medications from electronic health records (EHRs) is a safety-critical task that demands therapeutic coverage, explicit safety constraints, traceable justification, and continual adaptivity. Supervised neural models freeze at deployment and cannot reason about new phenotypes, while existing LLM pipelines are single-pass and lack a cross-case improvement loop. We propose **SEMPA**, a training-free agentic framework that couples a Proposer with a Critic in multi-round adversarial deliberation, grounds candidates with molecular-aware retrieval, contrastively evolves both agents’ natural-language policies under a semantic-anchor constraint, and enforces rule-based DDI and contraindication checks. On 100 MIMIC-IV encounters, SEMPA reaches 0.3116 Jaccard, 0.7295 F1, and a 0.0172 DDI rate, improving F1 by 57.7% and cutting DDI by 77.5% over the strongest supervised baseline. Two LLM judges rank SEMPA highest, and six-backbone studies confirm that gains derive from the framework rather than a specific model.

RNA’s conformational flexibility enables diverse biological functions but makes structure-guided design difficult. Although precise control of 3D structure is essential, existing methods often overlook the molecular surface, which critically shapes intermolecular interactions and functional outcomes. To address this, we propose gRFold, a multimodal framework that incorporates molecular surface information as a core design constraint. gRFold employs two geometric encoders: a Frame-Averaged Geometric Surface Encoder (FA-GSE) to learn E(3)-invariant surface features, and an Equivariant Backbone Graph Perceptron (EBGP) to capture backbone topology. The structural representations are integrated via hierarchical cross-attention to guide autoregressive generation; at inference, candidates are re-ranked by agreement between their predicted folds and the target base-pairing pattern. Across three RNA inverse-folding benchmarks covering RNA-protein complexes, monomeric RNAs and independently curated RNA-Puzzles targets, gRFold achieves strong sequence recovery and structural fidelity under both secondary-structure and 3D refolding evaluations, and ablations show that the surface and backbone branches contribute complementary gains. These results highlight the potential of surface-aware geometric modeling for structure-guided RNA design.

Symbolic regression is a powerful technique for discovering mathematical expressions that best fit observed data. While neural symbolic regression methods based on large-scale pre-trained models perform well on simple tasks, the reliance on fixed parametric knowledge typically limits their generalization to complex and diverse data distributions. To address this challenge, we propose a syntax-aware retrieval-augmented mechanism that leverages the syntactic structure of symbolic expressions to perform context-aware retrieval from a pre-constructed token datastore during inference. This mechanism enables the model to incorporate highly relevant non-parametric prior information to assist in expression generation. Additionally, we design an entropy-based confidence network that dynamically adjusts the fusion strength between neural and retrieved components by estimating predictive uncertainty. Extensive experiments on multiple symbolic regression benchmarks demonstrate that the proposed method significantly outperforms representative baselines, validating the effectiveness of retrieval augmentation in enhancing the generalization performance of neural symbolic regression models.

This study investigated and released the JADE, a corpus for Japanese definition modelling, which is a technique that automatically generates definitions of a given target word and phrase. It is a crucial technique for practical applications that assist language learning and education, as well as for those supporting reading documents in unfamiliar domains. Although corpora for development of definition modelling techniques have been actively created, their languages are mostly limited to English. In this study, a corpus for Japanese, named JADE, was created following the previous study that mines an online encyclopedia. The JADE provides about 630k sets of targets, their definitions, and usage examples as contexts for about 41k unique targets, which is sufficiently large to train neural models. The targets are both words and phrases, and the coverage of domains and topics is diverse. The performance of a pre-trained sequence-to-sequence model and the state-of-the-art definition modelling method was also benchmarked on JADE for future development of the technique in Japanese. The JADE corpus has been released and available online.

Definition generation techniques aim to generate a definition of a target word or phrase given a context. In previous studies, researchers have faced various issues such as the out-of-vocabulary problem and over/under-specificity problems. Over-specific definitions present narrow word meanings, whereas under-specific definitions present general and context-insensitive meanings. Herein, we propose a method for definition generation with appropriate specificity. The proposed method addresses the aforementioned problems by leveraging a pre-trained encoder-decoder model, namely Text-to-Text Transfer Transformer, and introducing a re-ranking mechanism to model specificity in definitions. Experimental results on standard evaluation datasets indicate that our method significantly outperforms the previous state-of-the-art method. Moreover, manual evaluation confirms that our method effectively addresses the over/under-specificity problems.