Clinical trials are critical for advancing medical treatments but remain prohibitively expensive and time-consuming. Accurate prediction of clinical trial outcomes can significantly reduce research and development costs and accelerate drug discovery. While recent deep learning models have shown promise by leveraging unstructured data, their black-box nature, lack of interpretability, and vulnerability to label leakage limit their practical use in high-stakes biomedical contexts. In this work, we propose AutoCT, a novel framework that combines the reasoning capabilities of large language models with the explainability of classical machine learning. AutoCT autonomously generates, evaluates, and refines tabular features based on public information without human input. Our method uses Monte Carlo Tree Search to iteratively optimize predictive performance. Experimental results show that AutoCT performs on par with or better than SOTA methods on clinical trial prediction tasks within only a limited number of self-refinement iterations, establishing a new paradigm for scalable, interpretable, and cost-efficient clinical trial prediction.

In this work, we introduce a novel approach that equips LLM agents with introspection, enhancing consistency and adaptability in solving complex tasks. Our approach prompts LLM agents to decompose a given task into manageable subtasks (i.e., to make a plan), and to continuously introspect upon the suitability and results of their actions. We implement a three-fold introspective intervention: 1) anticipatory reflection on potential failures and alternative remedy before action execution, 2) post-action alignment with subtask objectives and backtracking with remedy to ensure utmost effort in plan execution, and 3) comprehensive review upon plan completion for future strategy refinement. By deploying and experimenting with this methodology—a zero-shot approach—within WebArena for practical tasks in web environments, our agent demonstrates superior performance with a success rate of 23.5% over existing zero-shot methods by 3.5%. The experimental results suggest that our introspection-driven approach not only enhances the agent’s ability to navigate unanticipated challenges through a robust mechanism of plan execution, but also improves efficiency by reducing the number of trials and plan revisions by 45% needed to achieve a task.

In this work, we focus on a fundamental yet underexplored problem, event semantic classification in context, to help machines gain a deeper understanding of events. We classify events from six perspectives: modality, affirmation, specificity, telicity, durativity, and kinesis. These properties provide essential cues regarding the occurrence and grounding of events, changes of status that events can bring about, and the connection between events and time. To this end, this paper introduces a novel dataset collected for the semantic classification tasks and several effective models. By incorporating these event properties into downstream tasks, we demonstrate that understanding the fine-grained event semantics benefits downstream event understanding and reasoning via experiments on event extraction, temporal relation extraction, and subevent relation extraction.

Event causality identification (ECI), a process that extracts causal relations between events from text, is crucial for distinguishing causation from correlation. Traditional approaches to ECI have primarily utilized linguistic patterns and multi-hop relational inference, risking false causality identification due to informal usage of causality and specious graphical inference. In this paper, we adopt the Rubin Causal Model to identify event causality: given two temporally ordered events, we see the first event as the treatment and the second one as the observed outcome. Determining their causality involves manipulating the treatment and estimating the resultant change in the likelihood of the outcome. Given that it is only possible to implement manipulation conceptually in the text domain, as a work-around, we try to find a twin for the protagonist from existing corpora. This twin should have identical life experiences with the protagonist before the treatment but undergoes an intervention of treatment. However, the practical difficulty of locating such a match limits its feasibility. Addressing this issue, we use the synthetic control method to generate such a twin’ from relevant historical data, leveraging text embedding synthesis and inversion techniques. This approach allows us to identify causal relations more robustly than previous methods, including GPT-4, which is demonstrated on a causality benchmark, COPES-hard.

Temporal reasoning is the task of predicting temporal relations of event pairs. While temporal reasoning models can perform reasonably well on in-domain benchmarks, we have little idea of these systems’ generalizability due to existing datasets’ limitations. In this work, we introduce a novel task named TODAY that bridges this gap with temporal differential analysis, which as the name suggests, evaluates whether systems can correctly understand the effect of incremental changes. Specifically, TODAY introduces slight contextual changes for given event pairs, and systems are asked to tell how this subtle contextual change would affect relevant temporal relation distributions. To facilitate learning, TODAY also annotates human explanations. We show that existing models, including GPT-3.5, drop to random guessing on TODAY, suggesting that they heavily rely on spurious information rather than proper reasoning for temporal predictions. On the other hand, we show that TODAY’s supervision style and explanation annotations can be used in joint learning, encouraging models to use more appropriate signals during training and thus outperform across several benchmarks. TODAY can also be used to train models to solicit incidental supervision from noisy sources such as GPT-3.5, thus moving us more toward the goal of generic temporal reasoning systems.

We introduce RESIN-11, a new schema-guided event extraction&prediction framework that can be applied to a large variety of newsworthy scenarios. The framework consists of two parts: (1) an open-domain end-to-end multimedia multilingual information extraction system with weak-supervision and zero-shot learningbased techniques. (2) schema matching and schema-guided event prediction based on our curated schema library. We build a demo website based on our dockerized system and schema library publicly available for installation (https://github.com/RESIN-KAIROS/RESIN-11). We also include a video demonstrating the system.