Heloisa Oss Boll

Author directory

Also published as: Heloísa Oss Boll


2026

Early prediction of ICU mortality can support clinical decisions, but retrospective notes can contain future-event cues that cause leakage in clinical NLP. We evaluate leakage-aware modeling of Brazilian Portuguese ICU notes for mortality prediction using BRATECA. We compare 24-hour restriction, regex and LLM leakage auditing, neural and TF-IDF representations, and unrestricted-note baselines. In the 24-hour setting, models achieved AUROC 0.78-0.83; unrestricted notes reached around 0.95, indicating outcome-related information in late documentation. Regex found leakage signals in 21.13% of the notes, and the LLM audit identified additional semantic cases. Results highlight the need for temporal control and leakage auditing in clinical NLP.
Large language models (LLMs) are increasingly applied in clinical decision support, yet current evaluations rarely reveal whether their outputs reflect genuine medical reasoning or superficial correlations. We introduce DeVisE (Demographics and Vital signs Evaluation), a behavioral testing framework that probes fine-grained clinical understanding through controlled counterfactuals. Using intensive care unit (ICU) discharge notes from MIMIC-IV, we construct both raw (real-world) and template-based (synthetic) variants with single-variable perturbations in demographic (age, gender, ethnicity) and vital sign attributes. We evaluate eight LLMs, spanning general-purpose and medical variants, under zero-shot setting. Model behavior is analyzed through (1) input-level sensitivity, capturing how counterfactuals alter perplexity, and (2) downstream reasoning, measuring their effect on predicted ICU length-of-stay and mortality. Overall, our results show that standard task metrics obscure clinically relevant differences in model behavior, with models differing substantially in how consistently and proportionally they adjust predictions to counterfactual perturbations