This paper describes the NiuTrans neural machine translation systems of the WMT22 General MT constrained task. We participate in four directions, including Chinese→English, English→Croatian, and Livonian↔English. Our models are based on several advanced Transformer variants, e.g., Transformer-ODE, Universal Multiscale Transformer (UMST). The main workflow consists of data filtering, large-scale data augmentation (i.e., iterative back-translation, iterative knowledge distillation), and specific-domain fine-tuning. Moreover, we try several multi-domain methods, such as a multi-domain model structure and a multi-domain data clustering method, to rise to this year’s newly proposed multi-domain test set challenge. For low-resource scenarios, we build a multi-language translation model to enhance the performance, and try to use the pre-trained language model (mBERT) to initialize the translation model.