Open Information Extraction (OIE) is the task of extracting tuples of the form (subject, predicate, object), without any knowledge of the type and lexical form of the predicate, the subject, or the object. In this work, we focus on improving OIE quality by exploiting domain knowledge about the subject and object. More precisely, knowing that the subjects and objects in sentences are oftentimes named entities, we explore how to inject constraints in the extraction through constrained inference and constraint-aware training. Our work leverages the state-of-the-art OpenIE6 platform, which we adapt to our setting. Through a carefully constructed training dataset and constrained training, we obtain a 29.17% F1-score improvement in the CaRB metric and a 24.37% F1-score improvement in the WIRe57 metric. Our technique has important applications – one of them is investigative journalism, where automatically extracting conflict-of-interest between scientists and funding organizations helps understand the type of relations companies engage with the scientists.