Two key obstacles in biomedical relation extraction (RE) are the scarcity of annotations and the prevalence of instances without explicitly pre-defined labels due to low annotation coverage. Existing approaches, which treat biomedical RE as a multi-class classification task, often result in poor generalization in low-resource settings and do not have the ability to make selective prediction on unknown cases but give a guess from seen relations, hindering the applicability of those approaches. We present NBR, which converts biomedical RE as natural language inference formulation through indirect supervision. By converting relations to natural language hypotheses, NBR is capable of exploiting semantic cues to alleviate annotation scarcity. By incorporating a ranking-based loss that implicitly calibrates abstinent instances, NBR learns a clearer decision boundary and is instructed to abstain on uncertain instances. Extensive experiments on three widely-used biomedical RE benchmarks, namely ChemProt, DDI and GAD, verify the effectiveness of NBR in both full-set and low-resource regimes. Our analysis demonstrates that indirect supervision benefits biomedical RE even when a domain gap exists, and combining NLI knowledge with biomedical knowledge leads to the best performance gains.

Semantic typing aims at classifying tokens or spans of interest in a textual context into semantic categories such as relations, entity types, and event types. The inferred labels of semantic categories meaningfully interpret how machines understand components of text. In this paper, we present UniST, a unified framework for semantic typing that captures label semantics by projecting both inputs and labels into a joint semantic embedding space. To formulate different lexical and relational semantic typing tasks as a unified task, we incorporate task descriptions to be jointly encoded with the input, allowing UniST to be adapted to different tasks without introducing task-specific model components. UniST optimizes a margin ranking loss such that the semantic relatedness of the input and labels is reflected from their embedding similarity. Our experiments demonstrate that UniST achieves strong performance across three semantic typing tasks: entity typing, relation classification and event typing. Meanwhile, UniST effectively transfers semantic knowledge of labels and substantially improves generalizability on inferring rarely seen and unseen types. In addition, multiple semantic typing tasks can be jointly trained within the unified framework, leading to a single compact multi-tasking model that performs comparably to dedicated single-task models, while offering even better transferability.