While Large Language Models (LLMs) have achieved remarkable results across various benchmarks, their alignment with normative values often results in homogenized responses that fail to address diverse user preferences. Existing training-free methods often occupy valuable context windows through prompt engineering, while training-based methods typically remain static post-training, failing to support the continual optimization required in real-world settings. To address these challenges, we propose **COPE** (**C**ontinual **O**ptimization with **P**ersonalized embedding and self-**E**valuation), a novel optimization framework tailored for real-world-motivated interaction settings with sparse user feedback. Our framework assigns learnable personalized embeddings to each user and synergistically integrates preference capture, self-evaluation calibration, and personalized response optimization within a single update step. A key innovation of our method is the use of self-evaluation to generate proxy rewards, enabling continuous model updates even when explicit user feedback is unavailable. Experiments show that COPE consistently outperforms strong training-free and training-based baselines under sparse feedback, and remains complementary to Retrieval-Augmented Prompting (RAP). Further analyses confirm COPE’s reliable self-evaluation, meaningful preference patterns, stable general capabilities, and robustness under shifting preferences and alternative evaluators.

Artificial Intelligence (AI), along with the recent progress in biomedical language understanding, is gradually offering great promise for medical practice. With the development of biomedical language understanding benchmarks, AI applications are widely used in the medical field. However, most benchmarks are limited to English, which makes it challenging to replicate many of the successes in English for other languages. To facilitate research in this direction, we collect real-world biomedical data and present the first Chinese Biomedical Language Understanding Evaluation (CBLUE) benchmark: a collection of natural language understanding tasks including named entity recognition, information extraction, clinical diagnosis normalization, single-sentence/sentence-pair classification, and an associated online platform for model evaluation, comparison, and analysis. To establish evaluation on these tasks, we report empirical results with the current 11 pre-trained Chinese models, and experimental results show that state-of-the-art neural models perform by far worse than the human ceiling.