Computer-use agents (CUAs) interact with graphical interfaces through screenshots and low-level mouse and keyboard actions, yet the causal error may precede the terminal failure. We present **CUADebug**, a framework for localizing root causes in CUA trajectories and guiding re-execution. **CUADebug** includes a five-category, 30-subtype taxonomy; CUAErrorBench, a benchmark of 204 failed OSWorld trajectories with human root-cause annotations; and CUADebugger, a ReAct-style agent for root-cause analysis (RCA). CUADebugger iteratively selects trajectory steps, inspects paired before/after screenshots and action traces, and submits a structured diagnosis containing the causal step, taxonomy label, grounded evidence, and correction. CUADebugger performs RCA without per-trajectory human intervention; human annotations are used to evaluate RCA predictions and, in controlled re-rollout comparisons, to fix restart points. Task reasoning and control is the largest annotated failure category (110/204). CUADebugger improves L2 and Tag+Step Exact across three debugger backbones on the Claude-agent split; with Gemini 2.5 Pro, Tag+Step Exact rises from 11.1% to 19.4%. Single re-execution improves failure recovery from 13.89% to 29.86% (overall 61.77% to 68.14%); controlled continual re-execution improves it from 12.50% to 25.69% (overall 61.22% to 66.48%). Project page: cuadebug.github.io

Recent advancements in large language model (LLM) agents have significantly accelerated scientific discovery automation, yet concurrently raised critical ethical and safety concerns. To systematically address these challenges, we introduce SafeScientist, an innovative AI scientist framework explicitly designed to enhance safety and ethical responsibility in AI-driven scientific exploration. SafeScientist proactively refuses ethically inappropriate or high-risk tasks and rigorously emphasizes safety throughout the research process. To achieve comprehensive safety oversight, we integrate multiple defensive mechanisms, including prompt monitoring, agent-collaboration monitoring, tool-use monitoring, and an ethical reviewer component. Complementing SafeScientist, we propose SciSafetyBench , a novel benchmark specifically designed to evaluate AI safety in scientific contexts, comprising 240 high-risk scientific tasks across 6 domains, alongside 30 specially designed scientific tools and 120 tool-related risk tasks. Extensive experiments demonstrate that SafeScientist significantly improves safety performance by 35% compared to traditional AI scientist frameworks, without compromising scientific output quality. Additionally, we rigorously validate the robustness of our safety pipeline against diverse adversarial attack methods, further confirming the effectiveness of our integrated approach. The code and data will be available at https://github.com/ulab-uiuc/SafeScientist. Warning: this paper contains example data that may be offensive or harmful.

Automatic research with Large Language Models (LLMs) is rapidly gaining importance, driving the development of increasingly complex workflows involving multi-agent systems, planning, tool usage, code execution, and human-agent interaction to accelerate research processes. However, as more researchers and developers begin to use and build upon these tools and platforms, the complexity and difficulty of extending and maintaining such agentic workflows have become a significant challenge, particularly as algorithms and architectures continue to advance. To address this growing complexity, TinyScientist identifies the essential components of the automatic research workflow and proposes an interactive, extensible, and controllable framework that adapts easily to new tools and supports iterative growth. We provide an open-source codebase, an interactive web demonstration, and a PyPI Python package to make state-of-the-art auto-research pipelines broadly accessible to every researcher and developer.