Machine unlearning aims to remove the influence of designated training data while preserving model utility, but its behavior on tabular data remains underexplored. This gap is important because tabular prediction is widely used in high-stakes domains and is increasingly adapted to language models through record serialization and schema-aware prompting. We identify a key challenge that distinguishes tabular unlearning from unlearning in free-form text or other modalities: schema-induced forget–retain overlap. In serialized tabular data, records share fixed column-name/value slots, similar attribute ranges, and common output spaces. Consequently, a forget row may have nearby retain rows that rely on the same high-signal attributes, causing retain preservation to oppose the update required for forgetting. Motivated by this failure mode, we propose Conflict-Aware Unlearning (CAU), a schema-aware approach that reduces forget–retain interference by relaxing preservation constraints on retained rows that most conflict with the forget set. Across sample-level and feature-level unlearning on clinical and non-medical tabular tasks, more closely matches a retraining oracle while maintaining predictive utility and retain-region behavior. Our results show that reliable tabular LLM unlearning depends not only on the forgetting objective, but also on how retain constraints are constructed.

In real clinical practice, clinicians must sift through noisy and often conflicting information, progressively gathering and sequencing evidence before reaching conclusions. However, existing tuning methods for medical AI models are typically monologue-based — that is, models are fine-tuned on static question answering (QA) tasks or medical articles, which fail to reflect the interactive and iterative nature of clinical reasoning. To bridge this gap, we introduce MuddyMaze, a benchmark designed to expose the limitations of current monologue-based tuning, and construct a large dialogue dataset of 22.2k doctor–patient interactions that capture stepwise diagnostic reasoning validated by medical experts. Building on those, we propose dialogue-tuning, a new fine-tuning paradigm that captures the internal reasoning dynamics unfolding across interactions.

To assess the effectiveness of our approach, we evaluated dialogue-tuned models on MuddyMaze, where they outperform monologue-tuned baselines (e.g., MedQA) by +16.1% in one-round and +4.1% in multi-round evidence ranking, while maintaining or even improving accuracy on standard medical QA benchmarks (e.g., PubMedQA). These results indicate that dialogue-tuning not only enhances reasoning robustness and evidence integration but also preserves the factual precision of traditional QA performance.

Omni-modal LLMs aim to answer queries over heterogeneous inputs through a unified interface, but accepting these inputs does not guarantee using them. % The model’s confidence should change when an informative modality is removed. Existing autoregressive and diffusion multimodal LLMs typically optimize answer likelihood only under the full context, leaving multimodal shortcuts largely unconstrained. We study this problem through the lens of *intervention sensitive omni-modal prediction*, where confidence in the correct answer should decrease when protocol designated evidence is disrupted. We propose *OmniDenoise*, a diffusion MLLM framework built around the *Evidence Denoising Gap* (EDG), a diffusion native objective that compares gold token denoising losses under full and intervened contexts. EDG uses the token-by-timestep denoising trajectory as both a training signal and a diagnostic, without requiring token level evidence annotations. OmniDenoise further applies consistency distillation for efficient few step bidirectional denoising. Across tri-modal, clinical, and out-of-distribution omni-modal benchmarks, OmniDenoise substantially improves over diffusion baselines and remains competitive with strong autoregressive omni models. On OmniBench, the distilled model achieves 45.27% accuracy at 0.19 seconds per sample. On EHRXQA, EDG improves H-Acc from 36.9% to 43.9%, while the distilled student retains 42.6% with a 3.9× speedup.

Drug repurposing aims to identify new therapeutic uses for existing compounds and, compared with de novo drug discovery, offers a faster and more cost-effective path to clinical translation. However, the space of candidate drug–disease pairs is enormous and their underlying relationships often depend on complex multi-hop biological mechanisms, making it difficult to reliably predict which pairs represent true therapeutic relationships. Existing approaches tackle this from two directions: knowledge graph-based methods organize curated biomedical evidence into structured relational networks for grounded multi-hop reasoning, while LLM-based methods leverage pretrained knowledge to generate flexible mechanistic rationales. Yet neither is sufficient alone — KGs are confined to observed graph structure while LLMs lack factual grounding and risk hallucination. To address this gap, we propose DrugReason, a multi-view reasoning framework that integrates grounded KG reasoning with LLM-generated mechanistic inference for drug repurposing. DrugReason adaptively routes diverse reasoning paths to specialized experts conditioned on the query context, while a cross-expert distillation objective enables knowledge sharing without sacrificing expert specialization. Experiments on PharmaDB, DDInter, and DrugBank show that DrugReason improves average performance over strong single-view reasoning baselines and achieves competitive or superior results compared with graph-based alternatives, while providing interpretable routing-based predictions.

Despite the rapid advancement of Large Language Models (LLMs), uncertainty quantification in LLM generation is a persistent challenge. Although recent approaches have achieved strong performance by restricting LLMs to produce short or constrained answer sets, many real-world applications require long-form and free-form text generation. A key difficulty in this setting is that LLMs often produce responses that are semantically coherent yet factually inaccurate, while the underlying semantics are multifaceted and the linguistic structure is complex. To tackle this challenge, this paper introduces Interrogative Uncertainty Quantification (IUQ), a novel framework that leverages inter-sample consistency and intra-sample faithfulness to quantify the uncertainty in long-form LLM outputs. By utilizing an interrogate-then-respond paradigm, our method provides reliable measures of claim-level uncertainty and the model’s faithfulness. Experimental results across diverse model families and model sizes demonstrate the superior performance of IUQ over two widely used long-form generation datasets.

Although Large Language Models (LLMs) succeed in human-guided conversations such as instruction following and question answering, the potential of LLM-guided conversations—where LLMs direct the discourse and steer the conversation’s objectives—remains under-explored. In this study, we first characterize LLM-guided conversation into three fundamental components: (i) Goal Navigation; (ii) Context Management; (iii) Empathetic Engagement, and propose GuideLLM as an installation. We then implement an interviewing environment for the evaluation of LLM-guided conversation. Specifically, various topics are involved in this environment for comprehensive interviewing evaluation, resulting in around 1.4k turns of utterances, 184k tokens, and over 200 events mentioned during the interviewing for each chatbot evaluation. We compare GuideLLM with 6 state-of-the-art LLMs such as GPT-4o and Llama-3-70b-Instruct, from the perspective of interviewing quality, and autobiography generation quality. For automatic evaluation, we derive user proxies from multiple autobiographies and employ LLM-as-a-judge to score LLM behaviors. We further conduct a human-involved experiment by employing 45 human participants to chat with GuideLLM and baselines. We then collect human feedback, preferences, and ratings regarding the qualities of conversation and autobiography. Experimental results indicate that GuideLLM significantly outperforms baseline LLMs in automatic evaluation and achieves consistent leading performances in human ratings.

The rapid advancement of large language models (LLMs) has significantly improved their performance in code generation tasks. However, existing code benchmarks remain static, consisting of fixed datasets with predefined problems. This makes them vulnerable to memorization during training, where LLMs recall specific test cases instead of generalizing to new problems, leading to data contamination and unreliable evaluation results. To address these issues, we introduce DynaCode, a dynamic, complexity-aware benchmark that overcomes the limitations of static datasets. DynaCode evaluates LLMs systematically using a complexity-aware metric, incorporating both code complexity and call-graph structures. DynaCode achieves large-scale diversity, generating up to 189 million unique nested code problems across 4 units of code complexity and 16 types of call graphs. Results on 12 latest LLMs show an average performance drop of 16.8 to 45.7 compared to MBPP+, with performance progressively decreasing as complexity increases. This demonstrates DynaCode’s ability to effectively differentiate model performance based on code complexity and how different parts of a program interact. Our benchmark and evaluation code are available at https://github.com/HWH-2000/DynaCode.

Ambiguity is pervasive in real-world questions, yet large language models (LLMs) often respond with confident answers rather than seeking clarification. In this work, we show that question ambiguity is linearly encoded in the internal representations of LLMs and can be both detected and controlled at the neuron level. During the model’s pre-filling stage, we identify that a small number of neurons, as few as one, encode question ambiguity information. Probes trained on these Ambiguity-Encoding Neurons (AENs) achieve strong performance on ambiguity detection and generalize across datasets, outperforming prompting-based and representation-based baselines. Layerwise analysis reveals that AENs emerge from shallow layers, suggesting early encoding of ambiguity signals in the model’s processing pipeline. Finally, we show that through manipulating AENs, we can control LLM’s behavior from direct answering to abstention. Our findings reveal that LLMs form compact internal representations of question ambiguity, enabling interpretable and controllable behavior.

Current logical reasoning evaluations of Large Language Models (LLMs) primarily focus on single-turn and static environments, such as arithmetic problems. The crucial problem of multi-turn, strategic reasoning is under-explored. In this work, we analyze the multi-turn strategic reasoning of LLMs through text-driven complete- and incomplete-information gaming, e.g., board games (Tic-Tac-Toe, Connect-4) and poker games (Texas Hold’em Poker). Specifically, we consider two distinct scenarios: 1) Online Racing, featuring multiple LLMs/agents to facilitate direct competition and comparison; 2) Offline Probing, constructing targeted questions with verified ground truth to evaluate LLMs’ strategic behaviors. Experimental results demonstrate that existing state-of-the-art LLMs and reasoning schemes are largely ineffective for strategic reasoning tasks. To mitigate these limitations, we propose a simple yet effective Recursively Thinking-Ahead (ReTA) agent, incorporating a recursive prompting mechanism that automatically analyzes the opponents’ future moves/actions and assigns reward signals for these situations, to strengthen the strategic reasoning of LLMs. We hope our work could spur further research and exploration in the multi-turn strategic reasoning of LLMs. The code is available at https://github.com/jinhaoduan/ReTA.

Uncertainty quantification (UQ) in natural language generation (NLG) tasks remains an open challenge, exacerbated by the closed-source nature of the latest large language models (LLMs). This study investigates applying conformal prediction (CP), which can transform any heuristic uncertainty notion into rigorous prediction sets, to black-box LLMs in open-ended NLG tasks. We introduce a novel uncertainty measure based on self-consistency theory, and then develop a conformal uncertainty criterion by integrating the uncertainty condition aligned with correctness into the CP algorithm. Empirical evaluations indicate that our uncertainty measure outperforms prior state-of-the-art methods. Furthermore, we achieve strict control over the correctness coverage rate utilizing 7 popular LLMs on 4 free-form NLG datasets, spanning general-purpose and medical scenarios. Additionally, the calibrated prediction sets with small size further highlights the efficiency of our method in providing trustworthy guarantees for practical open-ended NLG applications.

Large Language Models (LLMs) show promising results in language generation and instruction following but frequently “hallucinate”, making their outputs less reliable. Despite Uncertainty Quantification’s (UQ) potential solutions, implementing it accurately within LLMs is challenging. Our research introduces a simple heuristic: not all tokens in auto-regressive LLM text equally represent the underlying meaning, as “linguistic redundancy” often allows a few keywords to convey the essence of long sentences. However, current methods underestimate this inequality when assessing uncertainty, causing tokens with limited semantics to be equally or excessively weighted in UQ. To correct this, we propose Shifting Attention to more Relevant (SAR) components at both token- and sentence-levels for better UQ. We conduct extensive experiments involving a range of popular “off-the-shelf” LLMs, such as Vicuna, WizardLM, and LLaMA-2-chat, with model sizes extending up to 33B parameters. We evaluate various free-form question-answering tasks, encompassing domains such as reading comprehension, science Q&A, and medical Q&A. Our experimental results, coupled with a comprehensive demographic analysis, demonstrate the superior performance of SAR. The code is available at https://github.com/jinhaoduan/SAR.