Lena Schindler-Gmelch

Author directory

2026

Previous work links Major Depressive Disorder (MDD) to linguistic and paralinguistic speech patterns, highlighting speech analysis as a potential diagnostic tool for remote monitoring or clinical decision support (CDS) systems. Recent attempts to build MDD diagnostic models primarily rely on the English (E-)DAIC corpus. Despite promising results, these works rarely evaluate cross-corpus generalization and rely on self-reported questionnaires, limiting their clinical utility. We introduce a new, clinically validated German corpus, EmpkinS-EKSpression, of semi-structured diagnostic interviews to test the reliability of spoken language-based measures of MDD. Our model achieves an F1-score of 0.86 on the EmpkinS-EKSpression dataset and 0.74 on E-DAIC via zero-shot cross-corpus transfer, suggesting that MDD detection models can generalize across corpora and languages despite differences in interview format and ground truth definition, supporting further development of CDS systems.