Large Language Models have demonstrated profound utility in the medical domain. However, their application to autonomous Electronic Health Records (EHRs) navigation remains constrained by a reliance on curated inputs and simplified retrieval tasks. To bridge the gap between idealized experimental settings and realistic clinical environments, we present AgentEHR. This benchmark challenges agents to execute complex decision-making tasks, such as diagnosis and treatment planning, requiring long-range interactive reasoning directly within raw and high-noise databases. In tackling these tasks, we identify that existing summarization methods inevitably suffer from critical information loss and fractured reasoning continuity. To address this, we propose RetroSum, a novel framework that unifies a retrospective summarization mechanism with an evolving experience strategy. By dynamically re-evaluating interaction history, the retrospective mechanism prevents long-context information loss and ensures unbroken logical coherence. Additionally, the evolving strategy bridges the domain gap by retrieving accumulated experience from a memory bank. Extensive empirical evaluations demonstrate that RetroSum achieves performance gains of up to 29.16% over competitive baselines, while significantly decreasing total interaction errors by up to 92.3%.

Large language models (LLMs) have achieved remarkable success across diverse tasks through large-scale pretraining. However, they remain prone to catastrophic forgetting in continual learning. To the best of our knowledge, this is the first work to identify noise accumulation in LoRA updates as a key cause of forgetting in continual learning. A preliminary two-task experiment demonstrates that removing less important components of the second task’s LoRA parameters improves performance on the first task, suggesting that later updates introduce noisy interference. Building on this insight, we propose Subspace-Denoised Low-Rank Adaptation (SLoRA), a simple and effective framework that filters noisy components from LoRA updates via subspace similarity with the base model. SLoRA is a regularization-free method without accessing data or gradients from previous tasks or modifying the training process. It offers two variants, SLoRA-Pre and SLoRA-Post, for online and offline continual learning, respectively. Extensive experiments across tasks and models validate the effectiveness of SLoRA. It improves final accuracy by up to 12%, reduces forgetting by 29%, and filters out over 30% of LoRA parameters identified as noisy. Our code is available at https://github.com/alina1031/SLoRA.