Large Language Models (LLMs) consistently excel in diverse medical Natural Language Processing (NLP) tasks, yet their substantial computational requirements often limit deployment in real-world healthcare settings. In this work, we investigate whether “small” LLMs (around one billion parameters) can effectively perform medical tasks while maintaining competitive accuracy. We evaluate models from three major families—Llama-3, Gemma-3, and Qwen3—across 20 clinical NLP tasks among Named Entity Recognition, Relation Extraction, Case Report Form Filling, Question Answering, and Argument Mining. We systematically compare a range of adaptation strategies, both at inference time (few-shot prompting, constraint decoding) and at training time (supervised fine-tuning, continual pretraining). Fine-tuning emerges as the most effective approach, while the combination of few-shot prompting and constraint decoding offers strong lower-resource alternatives. Our results show that small LLMs can match or even surpass larger baselines, with our best configuration based on Qwen3-1.7B achieving an average score +9.2 points higher than Qwen3-32B. We release a comprehensive collection of all the publicly available Italian medical datasets for NLP tasks, together with our top-performing models. Furthermore, we release an Italian dataset of 126M words from the Emergency Department of an Italian Hospital, and 175M words from various sources that we used for continual pre-training.

Case Report Forms (CRFs) are structured instruments widely used in clinical research to systematically collect patient information according to predefined protocols. In practice, CRFs are often manually completed by clinicians based on patients’ clinical reports, a process that is time-consuming and prone to inconsistencies. Despite their central role in medical studies, automatic population of CRFs from clinical narratives remains largely underexplored in the Natural Language Processing community, partly due to the scarcity of publicly available datasets. In this paper, we present the CRF Filling Shared Task, organized at the CL4Health Workshop at LREC 2026, which aims to advance research on automatic extraction of structured clinical information from unstructured patient notes. The task consists of assigning the correct value to a set of predefined CRF items given a clinical note. The target dataset is derived from a real-world CRF for dyspnea assessment, comprising 134 medical items with predefined value sets. The task is provided in two languages, Italian and English. We describe the dataset, the task formulation, and the evaluation framework, and discuss the participating systems and their results. By introducing this shared task, we aim to stimulate research on clinically applicable NLP systems for structured data extraction in healthcare.

Adapting Large Language Models to the medical domain remains an active area of research, with multiple strategies proposed to leverage annotated and unannotated data effectively. In this work, we propose a thesis outline to compare three common adaptation approaches—Instruction Tuning, Continual Pretraining, and Reasoning-oriented Training. We identify 5 dimensions to analyse: i) the interaction between the adaptation technique and the tasks; ii) the impact of the data size on the downstream performance; iii) the differences between datasets required by the three techniques; iv) the impact of the techniques given the model size; v) the impact of the techniques given the language.We construct an evaluation framework composed by 5 multilingual medical NLP tasks (named entity recognition, relation extraction, question answering, case report form filling, argument mining), spanning on 21 datasets in English, Italian, and Spanish, for a total of 61 combinations of language and sub-task.

Retrieval-Augmented Generation (RAG) systems are usually defined by the combination of a generator and a retrieval component that extracts textual context from a knowledge base to answer user queries. However, such basic implementations exhibit several limitations, including noisy or suboptimal retrieval, misuse of retrieval for out-of-scope queries, weak query–document matching, and variability or cost associated with the generator. These shortcomings have motivated the development of “Enhanced” RAG, where dedicated modules are introduced to address specific weaknesses in the workflow.More recently, the growing self-reflective capabilities of Large Language Models (LLMs) have enabled a new paradigm, often referred to as “Agentic” RAG. In this approach, an LLM orchestrates the entire process, deciding which actions to perform, when to perform them, and whether to iterate. Despite the rapid adoption of both paradigms, it remains unclear which approach is preferable under which conditions.In this work, we conduct an empirically driven evaluation of “Enhanced” and “Agentic” RAG across multiple scenarios and dimensions. Our results provide practical insights into the trade-offs between the two paradigms, offering guidance on selecting the most effective RAG design for real-world applications, considering both performance and costs.

Case Report Forms (CRFs) are largely used in medical research as they ensure accuracy, reliability, and validity of results in clinical studies. However, publicly available, well-annotated CRF datasets are scarce, limiting the development of CRF slot filling systems able to fill in a CRF from clinical notes. To mitigate the scarcity of CRF datasets, we propose to take advantage of available datasets annotated for information extraction tasks and to convert them into structured CRFs. We present a semi-automatic conversion methodology, which has been applied to the E3C dataset in two languages (English and Italian), resulting in a new, high-quality dataset for CRF slot filling. Through several experiments on the created dataset, we report that slot filling achieves 59.7% for Italian and 67.3% for English on a closed Large Language Models (zero-shot) and worse performances on three families of open-source models, showing that filling CRFs is challenging even for recent state-of-the-art LLMs.