Understanding the gaps between job requirements and university curricula is crucial for improving student success and institutional effectiveness in higher education. In this context, natural language processing (NLP) can be leveraged to generate granular insights into where the gaps are and how they change. This paper proposes a three-dimensional research framework that combines NLP techniques with economic and educational research to quantify the alignment between course syllabi and job postings. We elaborate on key technical details of the framework and further discuss its potential positive impacts on practice, including unveiling the inequalities in and long-term consequences of education-occupation alignment to inform policymakers, and fostering information systems to support students, institutions and employers in the school-to-work pipeline.