Deep learning models deployed in clinical settings face two major challenges: domain generalization (DG) and long-tailed (LT) recognition. DG requires learning domain-invariant features to ensure robustness across heterogeneous acquisition protocols and patient populations. However, we identify a fundamental trade-off: objectives that enforce domain invariance often suppress class-discriminative signals essential for long-tailed recognition.To address this, we propose the Agentic Causal Disentanglement (CANDICE) Framework, a modular architecture that integrates explicit clinical expertise from sonographers, radiologists, and specialists as a form of causal intervention. The framework combines clinical reasoning, causal representation learning, and automated pipeline construction to disentangle domain-invariant and class-discriminative features. By incorporating domain-specific causal knowledge, it effectively decouples the objectives of DG and LT learning. We evaluate CANDICE on 10 diverse medical imaging datasets spanning four modalities. The framework achieves an average performance improvement of 10.3% across both multi-domain and in-domain long-tailed tasks, demonstrating its effectiveness in handling distribution shifts while preserving minority class performance.

Human decision-making in safety-critical domains is governed by abstract policies that intentionally omit exhaustive preconditions/ triggers and contingencies. Executing such underspecified policies reliably in open-world settings remains a fundamental challenge for large language models (LLMs). We introduce NITI, Neural Bridging for Incremental Execution and Trigger Inference from Underspecified Human Policies, a neuro-symbolic framework that treats LLMs not as autonomous planners, but as execution-time concretizers of human intent. NITI incrementally executes abstract policies via verifier-grounded interfaces, infers implicit applicability conditions, repairs execution through neural bridging when assumptions fail, and halts safely under state inconsistency. We evaluate NITI on two structurally distinct embodied domains: a new benchmark of World Cubing Championship 2×2 Rubik’s Cube scrambles (n=50) and a safety-critical automated insulin dosing task. Across multiple frontier LLMs, NITI enables reliable long-horizon execution without task-specific training or search with minimal contextualization infence overhead, substantially outperforming one-shot and chain-of-thought baselines. Our results show that compositional, verifier-grounded execution is essential for safe human–AI collaboration in open-world decision-making. Code and benchmark available here - https://github.com/ImpactLabASU/ACLNITI

Design-time safety guarantees for human-centered autonomous systems (HCAS) often break down in open-world deployment due to uncertain human interaction. In practice, HCAS must follow a user-personalized safety plan, with the human providing external inputs to handle out-of-distribution events. Open-world safety planning for HCAS demands modeling dynamical systems, exploring novel actions, and rapid replanning when plans are invalidated or dynamics shift. No single state-of-the-art planner meets all these needs. We introduce an LLM-based architecture that automatically generates personalized safety plans. By itself, the LLM fares poorly at producing safe usage plans, but coupling it with a safety verifier—which evaluates plan safety over the planning horizon and feeds back quality scores—enables the discovery of safe plans. Moreover, fine-tuning the LLM on personalized models inferred from open-world data further enhances plan quality. We validate our approach by generating safe usage plans for artificial pancreas systems in automated insulin delivery for Type 1 Diabetes patients. Code: https://github.com/ImpactLabASU/LLMOpen