In this paper, we present three approaches for Natural Language Inference, Question Entailment Recognition and Question-Answering to improve domain-specific Information Retrieval. For addressing the NLI task, the UMLS Metathesaurus was used to find the synonyms of medical terms in given sentences, on which the InferSent model was trained to predict if the given sentence is an entailment, contradictory or neutral. We also introduce a new Extreme gradient boosting model built on PubMed embeddings to perform RQE. Further, a closed-domain Question Answering technique that uses Bi-directional LSTMs trained on the SquAD dataset to determine relevant ranks of answers for a given question is also discussed.