Information Extraction (IE), encompassing Named Entity Recognition (NER), Named Entity Linking (NEL), and Relation Extraction (RE), is critical for transforming the rapidly growing volume of scientific publications into structured, actionable knowledge. This need is especially evident in fast-evolving biomedical fields such as the gut-brain axis, where research investigates complex interactions between the gut microbiota and brain-related disorders. Existing biomedical IE benchmarks, however, are often narrow in scope and rely heavily on distantly supervised or automatically generated annotations, limiting their utility for advancing robust IE methods. We introduce GutBrainIE, a benchmark based on more than 1,600 PubMed abstracts, manually annotated by biomedical and terminological experts with fine-grained entities, concept-level links, and relations. While grounded in the gut-brain axis, the benchmark’s rich schema, multiple tasks, and combination of highly curated and weakly supervised data make it broadly applicable to the development and evaluation of biomedical IE systems across domains.

Document-Level Relation Extraction (DocRE) relies heavily on costly manually annotated datasets, while large distant supervision resources such as DocRED distant remain underexploited due to noise. We show that a critical yet overlooked source of noise lies in structural inconsistencies within relational triples, including violations of ontology constraints and logical contradictions.

We introduce an ontology-driven framework to quantify and enforce structural consistency in DocRE datasets. Our analysis reveals substantial structural noise in DocRED distant and demonstrates that such inconsistencies propagate to model predictions. Enforcing structural well-formedness during training significantly reduces logical contradictions and consistently improves generalization performance. These findings establish structural consistency as a missing axis of supervision in DocRE and highlight structural regularization as an effective strategy for leveraging distant data at scale.