Existing multi-LLM collaboration systems often encounter scalability challenges when integrating new LLMs and tasks, leading to suboptimal performance. To address this, we propose SMCS, a Scalable Multi-LLM Collaboration System designed to effectively coordinate multiple open-source LLMs. The system consists of two core components: a Retrieval-based Prior Selection (RPS) module, which dynamically selects the most suitable LLMs for each input, and an Exploration–Exploitation-Driven Posterior Enhancement (EPE) module, which fosters response diversity and selects high-quality outputs through a hybrid scoring mechanism. Experiments on eight mainstream benchmarks validate the effectiveness of our system: by integrating fifteen open-source LLMs, SMCS outperforms prevailing closed-source LLMs, e.g., GPT-4.1(+5.36%) and GPT-o3-mini(+5.28%) across multiple tasks. Remarkably, it even exceeds the average of best results on different datasets with open-source LLMs (+2.86%), significantly advancing the empirical performance frontier of open-source collaboration. The code is released at https://github.com/magent4aci/SMCS.

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale instruction-tuning dataset for multi-omics biological sequences, including DNA, RNA, proteins, and multi-molecules. This dataset bridges LLMs and complex biological sequence-related tasks, enhancing their versatility and reasoning while maintaining conversational fluency. We also highlight significant limitations of current state-of-the-art LLMs on multi-omics tasks without specialized training. To overcome this, we propose ChatMultiOmics, a strong baseline with a novel three-stage training pipeline, demonstrating superior biological understanding through Biology-Instructions. Both resources are publicly available, paving the way for better integration of LLMs in multi-omics analysis. The Biology-Instructions is publicly available at: https://github.com/hhnqqq/Biology-Instructions.

The scientific research paradigm is undergoing a profound transformation owing to the development of Artificial Intelligence (AI). Recent works demonstrate that various AI-assisted research methods can largely improve research efficiency by improving data analysis, accelerating computation, and fostering novel idea generation. To further move towards the ultimate goal (i.e., automatic scientific research), in this paper, we introduce Dolphin, a closed-loop LLM-driven framework to enhance the automation level of scientific research. Dolphin first generates novel ideas based on feedback from previous experiments and relevant papers ranked by the topic and task attributes. Then, the generated ideas can be implemented using a code template refined and debugged with the designed exception-traceback-guided local code structure. Finally, Dolphin automatically analyzes the results of each idea and feeds the results back to the next round of idea generation. Experiments are conducted on the benchmark datasets of different topics and a subset of MLE-bench. Results show that Dolphin can continuously improve the performance of the input topic in a loop. We highlight that Dolphin can automatically propose methods that are comparable to the state-of-the-art in some tasks such as 3D point classification.

Along with the performance improvement in NLP domain, the sizes of transformer-based language models (TLM) are also dramatically increased. Some prior works intend to compress TLM models into more compact forms, but do not fully consider the hardware characters may not support the efficient execution for these forms, leading to the deployment of TLM on hardware with noticeable acceleration is still challenging. This paper thoroughly designs a compression scheme named GPUSQ-TLM to maximally utilize the GPU-friendly 2:4 fine-grained structured sparsity and quantization characters. Especially, a dense TLM model is first pruned to meet the GPU’s acceleration constraint of sparse patterns with FP16 type, then it is further quantized into a fixed-point one by quantization-aware training, to provide an extra speedup for integer tensors on GPU. A mixed-strategy knowledge distillation of labels, logits and feature maps is used for best accuracy compensation during pruning and quantization process. Experiment results show GPUSQ-TLM scheme achieves state-of-the-art compression on TLM model of various encoder and decoder blocks with negligible accuracy degradation on SQuAD, GLUE, CNN-DM & XSum and WikiText benchmarking tasks. Moreover, GPUSQ-TLM can boost actual deployment performance by up to 4.08-4.25x latency and 6.18-6.79x throughput on A100 GPU.