Personalized glucose regulation remains a central yet unresolved challenge in precision nutrition, as postprandial glucose response varies substantially across individuals. Existing approaches based on glycemic indices fail to adequately account for such heterogeneity and lack the mechanism to dynamically adjust meals based on personal physiological feedback. In this context, recent advances in LLM-based agents offer a promising direction, as they enable context-aware reasoning and iterative refinement. Inspired by this, we propose a physio-feedback agentic loop, a unified system that integrates individualized absorption modeling with dietary intervention to regulate glucose response. Specifically, we develop a Physiology-Aware Glucose Predictor to model individualized absorption dynamics through a learnable Temporal Physiological Absorption Decay Module. We then construct a Prediction-Driven Two-Stage Meal Optimization Agent that iteratively refines real-world meals using predicted outcomes as explicit feedback. Through extensive experiments on multiple public datasets, we demonstrate that our method not only improves prediction accuracy but also effectively reduces glucose excursions. To the best of our knowledge, this paper marks the first step in integrating physiological learning with an LLM-based agent for personalized glucose regulation.

Precision healthcare, particularly for conditions like hypertension and cardiovascular disease, necessitates monitoring of dietary sodium intake. However, tracking this is hindered by the prevalence of hidden salt in cooking, such as sodium in soy sauce and ketchup. While recipes offer a valuable data source for dietary analysis, sodium-rich seasonings are frequently omitted or described ambiguously in instructions. To solve this issue, we propose SALT, a Sodium Assessing Level Tracking framework adopting an RAG framework to assess sodium content in recipes. Our framework first introduces a Joint-Factor Embedding Retrieval module to locate similar recipes with specified sodium content for addressing the lack of contextual references. These retrieved samples provide contexts for subsequent inference. Then we design a structured 4-hop Chain-of-Thought inference module to refine the vague estimation from language models through a multi-step sodium estimation. To facilitate our study, we further construct a recipe dataset SALT54k with 54,151 entries labeled with 11 sodium quantities across common seasonings. Results on SALT54k demonstrate that our method achieves state-of-the-art performance in sodium estimation. Additional real-world validations confirm the effectiveness of our method, demonstrating its potential as a practical solution for AI-assisted precision healthcare.