Gene expression analysis holds the key to many biomedical discoveries, yet extracting insights from raw transcriptomic data remains challenging due to the complexity of multiple large, semi-structured files and the need for extensive domain expertise. Current approaches either rely on inflexible workflows that fail in edge cases or fully autonomous agents that lack the precision required for rigorous scientific inquiry. GenoMAS addresses this by presenting a team of LLM-based agents that integrates structured workflows with autonomous adaptability, orchestrating diverse specialized agents through typed message-passing protocols. At its core lies a guided-planning framework where programming agents decompose task guidelines into Action Units and dynamically choose to advance, revise, bypass, or backtrack, maintaining logical coherence while adapting to the idiosyncrasies of genomic data. On the GenoTEX benchmark, GenoMAS achieves 89.13% CSC for preprocessing and 60.48% F₁ for identifying trait-associated genes, surpassing prior art by 10.61% and 16.85%. It again outperforms strong agent baselines on ScienceAgentBench and DiscoveryBench, two independent bioinformatics benchmarks beyond transcriptomics. Its analyses yield gene-phenotype associations that are biologically plausible and corroborated by the literature. Our code is available at https://github.com/Liu-Hy/GenoMAS.

Where someone looks is a nonverbal communication cue that children and adults readily use.How well can Vision-Language Models (VLMs) infer gaze targets? To construct evaluation stimuli, we captured 1,360 real-world photos of scenes in which a person gazes at one of several objects on a table. Importantly, we also controlled the gazer’s head orientation: sometimes it was directed toward the gaze target, sometimes toward a distractor object, and sometimes left unconstrained. We found a substantial performance gap between VLMs and humans, ruled out alternative explanations such as resolution and object-naming skills, and identified the main reason for the gap as VLMs inferring gaze direction using head orientation rather than eye appearance.Such a bias is likely due to data rather than architecture, as suggested by a proof-of-concept experiment finetuning a transformer-based vision model.Future work should investigate whether these findings hold broadly across various deep learning methods trained on existing data, and whether better data mitigates this problem for all architectures.Pinpointing the reason sets the stage for technologies that can interpret gaze targets to have more efficient interactions with humans.

Text-based role-playing models can imitate character styles, but often fail to capture scene atmosphere and evolving tension, which are crucial for immersive applications such as VR games and interactive narratives. We study video-grounded role-playing dialogue and introduce EBM-RL (Eye-Brain-Mouth Reinforcement Learning), a decoupled GRPO-based framework that separates observation ( lt;perception gt;), reasoning ( lt;think gt;), and utterance generation ( lt;answer gt;). This design mimics the human See-Think-Speak process, enabling the model to ground dialogue in visual perception before reasoning and response generation. To optimize this See-Think-Speak process, EBM-RL integrates complementary rewards for scene-text alignment, perceptual-cognitive utility, answer faithfulness, and format consistency. Extensive experiments show that EBM-RL substantially outperforms text-only role-playing baselines and comparable-scale VLM baselines, while remaining competitive with stronger larger-scale VLMs on visual grounding and situational persona metrics. Moreover, EBM-RL demonstrates strong zero-shot transfer to out-of-domain VideoQA benchmarks without additional fine-tuning. We also release an open-source dataset for video-grounded role-playing dialogue.

Text-to-image (T2I) models can be maliciously used to generate harmful content such as sexually explicit, unfaithful, and misleading or Not-Safe-for-Work (NSFW) images. Previous attacks largely depend on the availability of the diffusion model or involve a lengthy optimization process. In this work, we investigate a more practical and universal attack that does not require the presence of a target model and demonstrate that the high-dimensional text embedding space inherently contains NSFW concepts that can be exploited to generate harmful images. We present the Jailbreaking Prompt Attack (JPA). JPA first searches for the target malicious concepts in the text embedding space using a group of antonyms generated by ChatGPT. Subsequently, a prefix prompt is optimized in the discrete vocabulary space to align malicious concepts semantically in the text embedding space.We further introduce a soft assignment with gradient masking technique that allows us to perform gradient ascent in the discrete vocabulary space.We perform extensive experiments with open-sourced T2I models, e.g. stable-diffusion-v1-4 and closed-sourced online services, e.g. DALL·E 2 and Midjourney with black-box safety checkers. Results show that (1) JPA bypasses both text and image safety checkers, (2) while preserving high semantic alignment with the target prompt. (3) JPA demonstrates a much faster speed than previous methods and can be executed in a fully automated manner. These merits render it a valuable tool for robustness evaluation in future text-to-image generation research.