Currently, leveraging large language models (LLMs) for autism intervention is a significant yet challenging task, particularly when directly employing LLMs as an intervention doctor. Researchers have mainly focused on using prompt engineering for role play as an intervention doctor and integrating auxiliary elements such as visual stimuli to enhance the sensory experience of the intervention, while neglecting the challenge that LLMs’ inherent dialogue style and intervention strategies do not meet the requirements of clinical dialogue interventions. To fill the gap, we propose a comprehensive framework for training LLMs to conduct dialogue interventions in accordance with the principles of Applied Behavior Analysis (ABA) which is commonly used by clinicians. Specifically, we collected clinical recordings of dialogue interventions for autistic children and constructed the topic dialogue dataset ASD-iLLM-8k. By incorporating the system prompt based on the ABA and ASD-iLLM-8k dataset, we fine-tuned LLMs to develop ASD-iLLM. We also proposed a role-play strategy in which LLMs act as autistic children to comprehensively evaluate the doctor model’s capabilities at the dialogue level. Extensive experiments indicate that ASD-iLLM outperforms existing models in both automatic and human evaluation, with intervention strategies and dialogue style more closely resembling those of clinical intervention doctors. Our dataset, model, and code are available on https://github.com/Shuzhong-Lai/ASD-iLLM.