Safety alignment in large language models (LLMs) remains brittle against a growing spectrum of attacks. Jailbreak attacks bypass safety mechanisms through crafted prompts, while neuron-level attacks directly prune safety-critical neurons post-deployment. Both exploit a common weakness: safety-relevant information concentrates in a sparse neuron subset. We present NeuronGuard, a fine-tuning-stage defense that simultaneously hardens LLMs against both attack classes by redistributing safety signals across a broader set of neurons. NeuronGuard dynamically identifies safety-critical neurons via periodically refreshed per-layer linear classifiers, forces refusal behavior under deliberate neuron ablation, and applies KL-divergence regularization for distributional consistency. A randomized gradient projection strategy preserves downstream task utility by resolving conflicts between the defense and task objectives. We provide a formal guarantee that NeuronGuard strictly reduces the attack success rate (ASR) upper bound, and experiments across three LLMs, six state-of-the-art attack strategies, and multimodal settings confirm near-zero ASR while maintaining task accuracy, including against white-box adaptive adversaries.

Retrieval-augmented generation (RAG) improves the factuality of large language models by grounding responses in external documents, but it also exposes a critical security vulnerability: adversarial documents injected into the knowledge database can enter the context window and steer the model toward targeted incorrect answers. Existing post-retrieval defenses rely on instruction following, parametric knowledge, or text-level consistency, all of which can be imitated or optimized against by adaptive attackers. We propose RAGSentinel, a training-free, label-free defense for black-box RAG systems. RAGSentinel uses a surrogate encoder to measure query-conditioned hidden-state shifts induced by retrieved documents, removes shared topic directions, and filters poisoned documents as geometric outliers from a robust majority consensus. We prove that, under an honest-majority assumption and a representation-level separation condition, RAGSentinel exactly recovers a poison-free majority-sized context. Experiments across three question-answering datasets, three LLM families, and multiple poisoning attacks show that RAGSentinel consistently achieves low attack success rates while preserving competitive accuracy and remaining effective against adaptive attacks with full pipeline knowledge.