Document-level relation extraction aims to recognize relations among multiple entity pairs from a whole piece of article. Recent methods achieve considerable performance but still suffer from two challenges: a) the relational entity pairs are sparse, b) the representation of entity pairs is insufficient. In this paper, we propose Pair-Aware and Entity-Enhanced(PAEE) model to solve the aforementioned two challenges. For the first challenge, we design a Pair-Aware Representation module to predict potential relational entity pairs, which constrains the relation extraction to the predicted entity pairs subset rather than all pairs; For the second, we introduce a Entity-Enhanced Representation module to assemble directional entity pairs and obtain a holistic understanding of the entire document. Experimental results show that our approach can obtain state-of-the-art performance on four benchmark datasets DocRED, DWIE, CDR and GDA.