Safety alignment in Large Language Models (LLMs) remains highly fragile during fine-tuning, where even benign adaptation can degrade pre-trained refusal behaviors and enable harmful responses. Existing defenses typically constrain either weights or activations in isolation, without considering their coupled effects on safety. In this paper, we first theoretically demonstrate that constraining either weights or activations alone is insufficient for safety preservation. To robustly preserve safety alignment, we propose Coupled Weight and Activation Constraints (CWAC), a novel approach that simultaneously enforces a precomputed safety subspace on weight updates and applies targeted regularization to safety-critical features identified by sparse autoencoders. Extensive experiments across four widely used LLMs and diverse downstream tasks show that CWAC consistently achieves the lowest harmful scores with minimal impact on fine-tuning accuracy, substantially outperforming strong baselines even under high harmful data ratios.

LLM-based Multi-agent systems (MAS) have shown strong capabilities across a wide range of domains. Their success largely hinges on the collaboration topology design, which has emerged as a central research focus in the automated MAS design.However, existing approaches are fundamentally constrained by their reliance on homogeneous LLMs, which significantly limits overall system intelligence.In response to this limitation, we for the first time propose the concept of **Automated Design of Heterogeneous-LLMs-based MAS (ADHM)**.ADHM sheds light on a promising avenue for advancing collective intelligence, which focuses on the automated design of cost-effective MAS composed of diverse LLMsand roles to suit various queries.Toward this challenging goal, we propose **Hetero-Designer**, a novel pipeline that efficiently encodes intricate dependencies among queries, LLMs and roles through a novel Binary-Star Transformer and constructs Hetero-MAS in an autoregressive graph generation process. Extensive experiments demonstrate that **Hetero-Designer** is: (1) high-performing on various benchmarks, (2) economical in reducing overhead, (3) extensible to unseen LLMs and roles.

In this paper, we focus on the challenging yet practical problem of Continual Few-shot Relation Extraction (CFRE), which involves extracting relations in the continuous and iterative arrival of new data with only a few labeled examples. The main challenges in CFRE are overfitting due to few-shot learning and catastrophic forgetting caused by continual learning. To address these problems, we propose a novel framework called RK2DA, which seamlessly integrates prototype-based data augmentation and relational knowledge distillation. Specifically, RK2DA generates pseudo data by introducing Gaussian noise to the prototype embeddings and utilizes a novel two-phase multi-teacher relational knowledge distillation method to transfer various knowledge from different embedding spaces. Experimental results on the FewRel and TACRED datasets demonstrate that our method outperforms the state-of-the-art baselines.