When large language models are used in real-world scenarios, continual learning (CL) becomes a non-trivial problem. In particular, continual learning with modern LLMs is challenged both by the substantial computational costs induced by their massive parameter scale, and by the limitations of current CL methods, which are mainly designed to mitigate catastrophic forgetting while neglecting knowledge sharing across tasks. We further observe that models with stronger performance exhibit stronger inter-task connections. In light of the above challenges and findings, we propose Attribution Scores-based Soft Orthogonality Low-Rank Adaptation (ASO-LoRA), an effective and efficient framework that simultaneously facilitates knowledge transfer while mitigating catastrophic forgetting. Specifically, ASO-LoRA initially assigns task-specific parameter subspaces for new tasks utilizing multi-LoRA modules, enabling for efficient training and inference without relying on task labels. Then, ASO-LoRA leverages attribution scores to evaluate task similarity and employs soft orthogonality between task-specific subspaces, guiding gradient updates in directions that promote parameter isolation, achieving a balance between knowledge transfer and preservation. Experiments are carried out on both the T5-large and the LLaMA2-7B, showing ASO-LoRA’s superior performance and suitability as a plug-in CL solution for general Transformer-based LLMs. Code is available at https://github.com/736619821/ASO-LORA.

Medical Multimodal Large Language Models (Med-MLLMs) have shown great promise in medical visual question answering (Med-VQA). However, when deployed in low-resource settings where abundant labeled data are unavailable, existing Med-MLLMs commonly fail due to their medical reasoning capability bottlenecks: (i) the intrinsic reasoning bottleneck that ignores the details from the medical image; (ii) the extrinsic reasoning bottleneck that fails to incorporate specialized medical knowledge. To address those limitations, we propose AMANDA, a training-free agentic framework that performs medical knowledge augmentation via LLM agents. Specifically, our intrinsic medical knowledge augmentation focuses on coarse-to-fine question decomposition for comprehensive diagnosis, while extrinsic medical knowledge augmentation grounds the reasoning process via biomedical knowledge graph retrieval. Extensive experiments across eight Med-VQA benchmarks demonstrate substantial improvements in both zero-shot and few-shot Med-VQA settings. The code is available at https://github.com/REAL-Lab-NU/AMANDA.