Active learning is an algorithmic approach that strategically selects a subset of examples for labeling, with the goal of reducing workload and required resources. Previous research has applied active learning to Neural Machine Translation (NMT) for high-resource or well-represented languages, achieving significant reductions in manual labor. In this study, we explore the application of active learning for NMT in the context of Mapudungun, a low-resource language spoken by the Mapuche community in South America. Mapudungun was chosen due to the limited number of fluent speakers and the pressing need to provide access to content predominantly available in widely represented languages. We assess both model-dependent and model-agnostic active learning strategies for NMT between Spanish and Mapudungun in both directions, demonstrating that we can achieve over 40% reduction in manual translation workload in both cases.