Spoken language ability is highly heterogeneous in Autism Spectrum Disorder (ASD), which complicates efforts to identify linguistic markers for use in diagnostic classification, clinical characterization, and for research and clinical outcome measurement. Machine learning techniques that harness the power of multivariate statistics and non-linear data analysis hold promise for modeling this heterogeneity, but many models require enormous datasets, which are unavailable for most psychiatric conditions (including ASD). In lieu of such datasets, good models can still be built by leveraging domain knowledge. In this study, we compare two machine learning approaches: the first approach incorporates prior knowledge about language variation across middle childhood, adolescence, and adulthood to classify 6-minute naturalistic conversation samples from 140 age- and IQ-matched participants (81 with ASD), while the other approach treats all ages the same. We found that individual age-informed models were significantly more accurate than a single model tasked with building a common algorithm across age groups. Furthermore, predictive linguistic features differed significantly by age group, confirming the importance of considering age-related changes in language use when classifying ASD. Our results suggest that limitations imposed by heterogeneity inherent to ASD and from developmental change with age can be (at least partially) overcome using domain knowledge, such as understanding spoken language development from childhood through adulthood.

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and the presence of restricted, repetitive patterns of behaviors and interests. Prior research suggests that restricted patterns of behavior in ASD may be cross-domain phenomena that are evident in a variety of modalities. Computational studies of language in ASD provide support for the existence of an underlying dimension of restriction that emerges during a conversation. Similar evidence exists for restricted patterns of facial movement. Using tools from computational linguistics, computer vision, and information theory, this study tests whether cognitive-motor restriction can be detected across multiple behavioral domains in adults with ASD during a naturalistic conversation. Our methods identify restricted behavioral patterns, as measured by entropy in word use and mouth movement. Results suggest that adults with ASD produce significantly less diverse mouth movements and words than neurotypical adults, with an increased reliance on repeated patterns in both domains. The diversity values of the two domains are not significantly correlated, suggesting that they provide complementary information.