Pre-trained LLMs have demonstrated substantial capabilities across a range of conventional natural language processing (NLP) tasks, such as summarization and entity recognition. In this paper, we explore the application of LLMs in the generation of high-quality protein sequences. Specifically, we adopt a suite of pre-trained LLMs, including Mistral-7B, Llama-2-7B, Llama-3-8B, and gemma-7B, to produce valid protein sequences. All of these models are publicly available (https://github.com/KamyarZeinalipour/protein-design-LLMs).Unlike previous work in this field, our approach utilizes a relatively small dataset comprising 42,000 distinct human protein sequences. We retrain these models to process protein-related data, ensuring the generation of biologically feasible protein structures. Our findings demonstrate that even with limited data, the adapted models exhibit efficiency comparable to established protein-focused models such as ProGen varieties, ProtGPT2, and ProLLaMA, which were trained on millions of protein sequences. To validate and quantify the performance of our models, we conduct comparative analyses employing standard metrics such as pLDDT, RMSD, TM-score, and REU. Furthermore, we commit to making the trained versions of all four models publicly available, fostering greater transparency and collaboration in the field of computational biology.

Crossword puzzles are popular linguistic games often used as tools to engage students in learning. Educational crosswords are characterized by less cryptic and more factual clues that distinguish them from traditional crossword puzzles. Despite there exist several publicly available clue-answer pair databases for traditional crosswords, educational clue-answer pairs datasets are missing. In this article, we propose a methodology to build educational clue generation datasets that can be used to instruct Large Language Models (LLMs). By gathering from Wikipedia pages informative content associated with relevant keywords, we use Large Language Models to automatically generate pedagogical clues related to the given input keyword and its context. With such an approach, we created clue-instruct, a dataset containing 44,075 unique examples with text-keyword pairs associated with three distinct crossword clues. We used clue-instruct to instruct different LLMs to generate educational clues from a given input content and keyword. Both human and automatic evaluations confirmed the quality of the generated clues, thus validating the effectiveness of our approach.

This paper presents the first Arabic crossword puzzle generator driven by advanced AI technology. Leveraging cutting-edge large language models including GPT4, GPT3-Davinci, GPT3-Curie, GPT3-Babbage, GPT3-Ada, and BERT, the system generates distinctive and challenging clues. Based on a dataset comprising over 50,000 clue-answer pairs, the generator employs fine-tuning, few/zero-shot learning strategies, and rigorous quality-checking protocols to enforce the generation of high-quality clue-answer pairs. Importantly, educational crosswords contribute to enhancing memory, expanding vocabulary, and promoting problem-solving skills, thereby augmenting the learning experience through a fun and engaging approach, reshaping the landscape of traditional learning methods. The overall system can be exploited as a powerful educational tool that amalgamates AI and innovative learning techniques, heralding a transformative era for Arabic crossword puzzles and the intersection of technology and education.