This study presents a new methodology to search sign language lexica, using a full sign as input for a query. Thus, a dictionary user can look up information about a sign by signing the sign to a webcam. The recorded sign is then compared to potential matching signs in the lexicon. As such, it provides a new way of searching sign language dictionaries to complement existing methods based on (spoken language) glosses or phonological features, like handshape or location. The method utilizes OpenPose to extract the body and finger joint positions. Dynamic Time Warping (DTW) is used to quantify the variation of the trajectory of the dominant hand and the average trajectories of the fingers. Ten people with various degrees of sign language proficiency have participated in this study. Each subject viewed a set of 20 signs from the newly compiled Ghanaian sign language lexicon and was asked to replicate the signs. The results show that DTW can predict the matching sign with 87% and 74% accuracy at the Top-10 and Top-5 ranking level respectively by using only the trajectory of the dominant hand. Additionally, more proficient signers obtain 90% accuracy at the Top-10 ranking. The methodology has the potential to be used also as a variation measurement tool to quantify the difference in signing between different signers or sign languages in general.